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erythematosus abnormal aptt bruising pt bleeding classification clues comparison druginduced hemostasis management mimickers myopathy myositis peds purpura signs symptoms system
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... 69% - Malar rash ... Diagnosis and Lupus ... #Systemic #Lupus ... #rheumatology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Early liver disease ... associated with systemic ... #Causes #diagnosis ... #differential # ... hematology #coagulation
Top 10 situations when to think about lupus 1) Inflammatory joint pain (especially in the wrists and
the face (many differential ... including in children (pediatric ... #diagnosis #sle ... #clues #system ... erythematosus #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
NPSLE rare, Malar rash ... months) and of autoantibodies ... months to years) Systemic ... #table #rheumatology ... #diagnosis #management
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... • Reduced liver ... associated with systemic ... #Causes #diagnosis ... hematology #coagulation
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... • Anti-Ro/SSA autoantibodies ... permanent alopecia Differential ... #Systemic #Lupus ... #Rheumatology
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
Causes of Purpura ... (systemic lupus ... intravascular coagulation ... #peds #pediatrics ... #diagnosis #differential
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
of Hemostasis - Differential ... Diagnosis Framework ... the PT remains prolonged ... discern these causes ... #Diagnosis #Hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... mucositis - Rash ... Diagnosis: Systemic ... vasculitis, and SLE ... #diagnosis #rheumatology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Symptoms: • Gottron rash ... Mechanic's hands Autoantibodies ... • Conduction system ... statins - probably caused ... Myositis #Myopathy #rheumatology
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