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diagnosis differential algorithm cardiology nutrition heartfailure hematology hfref pathophysiology treatment ascorbicacid ckd fatigue guidelines hemodialysis malabsorption mds myelitis myelodysplasia myelodysplastic
Iron Deficiency in Heart Failure Pathophysiology: Chronic heart failure leads to an increase in inflammatory cytokines → Inflammation
Iron Deficiency ... Pathophysiology: Chronic ... ng/mL (absolute ID ... 20% (functional ID ... #deficiency #CHF
Causes of Iron Deficiency • Diet: ↓ Intake, e.g. vegan, Malnutrition, Polyphenol / tannins, ↓ Vitamin
Causes of Iron Deficiency ... Inflammation: IBD ... , Chronic disease ... #Deficiency #Causes ... differential #diagnosis #anemia
Iron Deficiency in Heart Failure - Diagnosis and Treatment Algorithm Diagnosis: Ferritin <100 ng/mL (absolute ID) OR
Iron Deficiency ... ng/mL (absolute ID ... 20% (functional ID ... HF with iron deficiency ... #deficiency #CHF
Causes of Iron Deficiency • Inadequate Intake: Vegetarian/vegan diet, Malnutrition • Increased Body Needs: Infants/preschoolers, Pregnancy,
Causes of Iron Deficiency ... Elite athletes • Chronic ... Loss (without anaemia ... Inflammatory Disease (IBD ... , cancer) #Iron
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... : • Acute or Chronic ... Inflammatory: • IBD ... malignancy • Iron ... deficiency anemia
Fatigue and IBD Algorithm • 40-50% patients have fatigue despite clinical remission • Risk factors: BMI,
Fatigue and IBD ... Crohn's > UC Anemia ... and IBD Pearls: ... IDA and active IBD ... /other causes •
Causes of Fat Malabsorption - Differential Diagnosis Biliary Duct Obstruction • Autoimmune— PBC, PSC • Infection— liver
Causes of Fat Malabsorption ... • Autoimmune— Crohn's ... - Acquired • Chronic ... Pancreatic lipase deficiency ... Celiac disease • IBD
Widened Pulse Pressure - Differential Diagnosis and Pathophysiology Pulse pressure is the difference between the systolic blood
conditions) • Severe iron ... deficiency anemia ... disorders - Chronic ... atrial fibrillation at ... #cardiology
Scurvy (Vitamin C Deficiency) - Diagnosis and Management Vitamin C is required for hydroxylation of proline residues
Scurvy (Vitamin C Deficiency ... Diagnosis and Management ... Bone Groups at ... can lead to iron ... , or any other cause
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
• Mean age at Dx ... Marrow Failure • Chronic ... or folic acid deficiency ... treatments • Copper deficiency ... rings of excess iron
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