11 results
Metformin Associated Lactic Acidosis (MALA) 

Pathophysiology of MALA
 - Metformin interferes with the activity of the
Acidosis (MALA) Pathophysiology ... and acute kidney injury ... also includes symptoms ... LacticAcidosis #Toxicity ... Toxicology #Diagnosis #Management
 Acute Iron Poisoning

There are five classically described phases of toxicity:
Gastrointestinal phase (~6 hours post-ingestion)
 -
described phases of toxicity ... caustic mucosal injury ... post-ingestion) - Symptom ... caustic bowel injury ... Toxicology #Diagnosis #Management
Statin Induced Muscle Toxicity - Summary

Clinical Presentation:
 • Elevations of serum creatine kinase with proximal myalgia
Induced Muscle Toxicity ... Direct muscle injury ... Risk of muscle injury ... Statin #muscle #toxicity ... myopathy #diagnosis #management
Scurvy (Vitamin C Deficiency) - Diagnosis and Management

Vitamin C is required for hydroxylation of proline residues
Diagnosis and Management ... musculoskeletal symptoms ... Psychiatric symptoms ... beta-spectrin, which is crucial ... #AscorbicAcid #Pathophysiology
Amiodarone Induced Lung Toxicity Summary

Who?
• 5% of patients
• Dose ≥ 400 mg per day

How?  Possible
Amiodarone Induced Lung Toxicity ... cytotoxic lung injury ... gradually with symptoms ... Improvement in symptoms ... Pulmonary #diagnosis #management
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
to local skin injury ... meningitis), MCC CNS symptoms ... inhibitors • Uveitis- Ophthalmology ... Syndrome #diagnosis #management ... #signs #symptoms
Posterior Reversible Encephalopathy Syndrome (PRES) Overview

Clinico-Radiological Syndrome, characterized by:
 • Headache
 • Seizures
 • Altered mental
Etiology: • Pathophysiology ... Neurological symptoms ... Medication/Drug toxicity ... Syndrome #diagnosis #management
Transverse Myelitis Overview

Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
monophasic Pathophysiology ... Presentation: Injury ... Bilateral signs and/or symptoms ... Myelitis #diagnosis #management
Chemical Eye Injury: Pathogenesis and clinical findings
Exogenous chemical to the eye and/or adnexa
 • Ammonia, sodium
Chemical Eye Injury ... EMERGENCY: immediate management ... following initial management ... #Eye #Ocular #opthalmology ... #pathophysiology
Hemophagocytic Lymphohistiocytosis (HLH)

High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
recognition and management ... or triggers) is crucial ... Common Signs and Symptoms ... Pathophysiology ... Approach • Initial management