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differential causes acidosis decrease dm2 erythematosus false hba1c hemolytic hgba1c increase infections infectiousdiseases lactate lactic lupus mycobacteria nontuberculous ntm reduction
Causes of False Elevation and Reduction in HbA1c == False Elevation == Decreased RBC turnover • Iron, B-12,
• Asplenia Laboratory ... High Glucose Content ... blood loss • Hemolytic ... anemia • Splenomegaly ... Increase #Decrease #Diagnosis
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Diagnosis Framework ... Defects: Sickle cell anemia ... Hypophostphatemia Laboratory ... #hematology
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... for Hemolytic Anemia ... Hypersplenism • AIHA ... #classification ... #hematology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
TTP - Laboratory ... result in severe anemia ... anemia Indirect ... Mild-to-moderate elevation ... #Workup #Hematology
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
appropriate clinical context ... - assess other laboratory ... Arterial Oxygen Content ... 30mmHg) - Severe anemia ... #typea #typeb #classification
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
and fever) and laboratory ... Skin Disease Classification ... syndrome in the context ... : • AIHA 10% • ... lymphopenia, low PLT • Anemia
Nontuberculous Mycobacteria (NTM) Infections Mycobacterial species other than those belonging to the Mycobacterium tuberculosis complex and
Growers (Runyon Classification ... Hematologic malignancy ... gastrointestinal symptoms (elevations ... Bone Marrow - Anemia ... discomfort, • +/- Hemoptysis
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