17 results
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Malignancy (e.g. hematologic ... extremity edema, active ... vein thrombosis Hematologic ... activity • C3 ... CRP normal, ESR active
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Systemic Lupus Erythematosus ... with more severe disease ... activity Anti-Ro ... Systemic #Lupus #Erythematosus ... Summary #diagnosis #rheumatology
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
purpuric macules • Erythematous ... • Ulcerated, erythematous ... vessels with a certain ... Polyangiitis #GPA #dermatology ... rash #diagnosis #rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Systemic Lupus Erythematosus ... Cerebrovascular Disease ... , PRES Pathophysiology ... Systemic #Lupus #Erythematosus ... CNS #neurology #rheumatology
Erythema Annulare Centrifugum (EAC),
This is erythema annulare centrifugum (EAC), one of the “figurate erythemas.” These lesions
lags behind the active ... drugs, systemic disease ... clinical #photo #dermatology ... #skinrash
Tuberculosis Overview

10 million new M. tuberculosis infections/year
Facultative intracellular rod-shaped bacteria
Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
tuberculosis (LTBI) Pathophysiology ... Droplets that contain ... Chronic kidney disease ... Progressive lung disease ... Disease: Hematogenous
Tuberculosis Overview

10 million new M. tuberculosis infections/year
Facultative intracellular rod-shaped bacteria
Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
tuberculosis (LTBI) Pathophysiology ... Droplets that contain ... Chronic kidney disease ... Progressive lung disease ... Disease: Hematogenous
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
during hemolytic disease ... systemic lupus erythematosus ... cytokines, which activate ... Classification #Pathophysiology
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
Association with disease ... activity (when ... with auto-immune diseases ... Systemic #lupus #erythematosus ... #diagnosis #rheumatology
Autoimmune Hepatitis

Clinical Presentation
 - Highly variable clinical presentation, from subclinical disease to acute liver failure.
 -
from subclinical disease ... IgG > 2x ULN - Certain ... azathioprine (check TPMT activity ... Diagnosis #Management #Hepatology