37 results
Hemolytic anemia in Wilson's disease

#Wilsons #Disease #hemolytic #anemia #Hematology #pathophysiology
anemia in Wilson's disease ... #Wilsons #Disease ... hemolytic #anemia #Hematology ... #pathophysiology
Cholestatic Liver Disease: Primary Biliary Cirrhosis vs Primary Sclerosing Cholangitis

#pathophysiology #pbc #psc #hepatology #comparison
Cholestatic Liver Disease ... Cholangitis #pathophysiology ... #pbc #psc #hepatology
Ascites - Differential Diagnosis
Chronic liver disease (cirrhosis or chronic hepatitis) - 80%
Underlying malignancy - 10%
Congestive heart
Chronic liver disease ... Chlamydia (*Fitz-Hugh-Curtis ... HIV-related, Renal Disease ... Differential #Diagnosis #hepatology
Mixing Study
 • Clotting tests can be abnormal due to either a clotting factor deficiency, or
normal factor activity ... 50% of normal activity ... Study #diagnosis #hematology ... #pathophysiology ... #hematology #laboratory
Mechanisms Driving Increased Thrombosis and Bleeding in Liver Disease
Increased Thrombosis 
Increased Platelet-Vesset Wall Interaction 
 •
Bleeding in Liver Disease ... Clot #Cirrhosis #Pathophysiology ... #Hepatology #Liver
Primary Biliary Cirrhosis - Pathophysiology
Environmental Risk Factors: Geographic location, Smoking, Microbial triggers, Xenobiotics, Nail polish
Epigentics Risk
Biliary Cirrhosis - Pathophysiology ... female-predominant disease ... of autoimmune disease ... relative with PBC Pathophysiology ... #hepatology
Sickle Cell Disease - Pathophysiology of disease and complications 

Due to the deformed shape, HbS induces
Sickle Cell Disease ... - Pathophysiology ... of disease and ... #Pathophysiology ... Complications #Hematology
Hemophilia - Diagnosis and Management
Diagnosis:
 • Consistent bleeding history (unless screening for disease in family members
screening for disease ... with established disease ... Individual factor activity ... those with severe disease ... Management #treatment #hematology
Basophilia - Differential Diagnosis Framework

Basophils < 1% of the total white blood cell count
Basophils function similarly
to mast cells- contain ... Colitis and Crohn’s Disease ... Diagnosis #causes #hematology
Autoimmune Hepatitis

Clinical Presentation
 - Highly variable clinical presentation, from subclinical disease to acute liver failure.
 -
from subclinical disease ... IgG > 2x ULN - Certain ... azathioprine (check TPMT activity ... Diagnosis #Management #Hepatology