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rheumatology diagnosis erythematosus systemic differential management types vasculitis clinical criteria cryoglobulinemia cryoglobulins dermatology dil drug drugs eularacr medications nephritis nephrology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Rare (SSA+ for cutaneous ... rare), Topics for cutaneous-DIL ... life-threatening • Treatment ... Lupusreference #druginduced ... #lupus #sle #comparison
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... domain: Fever • Cutaneous ... , Acute cutaneous ... #EULARACR #Classification ... #Criteria #SLE
Lupus Classification Spontaneous Lupus - Cutaneous Lupus Erythematosus (CLE) - Systemic Lupus Erythematosus Drug-Induced Lupus - Drug-Induced
Lupus Classification ... - Cutaneous Lupus ... Erythematosus (CLE ... (SCLE-DIL) - ... #Classification
Cutaneous Lupus Erythematosus • Acute Cutaneous Lupus (ACLE) • Neutrophilic Dermatoses • Vascular Lesions •
Cutaneous Lupus ... Lupus (ACLE) ... Lupus (SCLE) ... Lupus (ICLE) ... #rheumatology #classification
Symptoms Distinguishing Groups of Cutaneous Drug Reactions IgE-mediated reactions: • Onset minutes to hours into treatment course
Distinguishing Groups of Cutaneous ... to hours into treatment ... Onset days into treatment ... dermatology #clinical #comparison ... #classification
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Skin Disease Classification ... : • Acute cutaneous ... scarring • Subacute cutaneous ... inflammation Cutaneous
Management of Lupus Nephritis Lupus nephritis (LN) in 10 to 40% of SLE Hallmark = proteinuria 20.5 g/g
Nephritis Lupus ... in 10 to 40% of SLE ... severity (ISN/RPS classification ... by 12 months Classification ... Nephritis #Management #treatment
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
is rare in DIL, SCLE-DIL ... Rare (SSA+ for cutaneous ... rare), Topics for cutaneous-DIL ... Lupusreference #DrugInduced ... #diagnosis #treatment
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
diseases: - 10% SLE ... Henoch-Schönlein purpura) • Cutaneous ... (e.g. systemic lupus ... erythematosus (SLE ... diagnosis #types #classification
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
aphthous ulcers, cutaneous ... such as systemic lupus ... strong sign of cutaneous ... vasculitis, and SLE ... #rheumatology #classification
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