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Cyclosporine - common immunosuppressant for transplant rejection prevention.  Originally isolated from fungi in the 1970's.

#Pharmacology
Cyclosporine - common ... #Pharmacology #Cyclosporine
Drug-induced gingival enlargement is a side-effect of certain drugs where the gingival tissue is not the
enlargement, 30% with cyclosporin ... druginducedgingivalenlargement #nifedipine #cyclosporine
Sebaceous hyperplasia 
 - Yellow papule 
 - Donut-shape 
 - Central umbilication 
 - Telangiectasia
actinic damage and cyclosporine
Utilization of Antibiotics as Antidotes

Valproic Acid Toxicity:
Carbapenems 

Amatoxin Mushrooms: 
Polymyxin B, Penicillin, Cyclosporine

Infographic by Mike O'Brien
@MikeEMPharmD

#Antibiotics
B, Penicillin, Cyclosporine
Drugs causing hyperkalemia
 • Impaired release of renin: NSAIDs, Beta blockers, Cyclosporine, tacrolimus, Diabetes, Elderly
 •
Beta blockers, Cyclosporine
Drugs that Impair Renal Potassium Excretion 

Decreased ENaC channel function: Amiloride, Triamterene, Pentamidine
Decreased Aldosterone Synthesis: Heparin,
Receptor Function: Cyclosporine
Immunosuppression in Transplantation
Induction (I):
 - Basiliximab (Simulect)
 - Alemtuzumab (Campath)
 - Rituximab
 - Anti-Thymocyte Globulin (ATG)
Induction
Astagraf) - Cyclosporine
Immunosuppressive Medications in Systemic Lupus Erythematosus (SLE)
 - MTX (oral, subcutaneous)
 - AZA (oral) 
 -
Calcineurin inhibitors (cyclosporine
Hypomagnesemia - Differential Diagnosis
Renal Causes of Hypomagnesemia - Familial:
Bartter syndrome and Gitelman syndrome, Isolated recessive hypomagnesemia,
cisplatin, Tacrolimus, cyclosporine
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
Inhibitors (Tacrolimus, Cyclosporine