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diagnosis differential algorithm management causes nephrology hypokalemia pharmacology cardiology potassium treatment ekg hypercalcemia endocrinology table ecg clinical medications pathophysiology workup
Causes of Hyperkalemia - Differential Diagnosis Framework • Cellular Shift: - Exercise
Causes of Hyperkalemia ... blockers, digitalis, cyclosporine ... tacrolimus - Hyperkalemic ... heparin, NSAIDS, cyclosporine ... Medicine @ucsdim #Hyperkalemia
Drugs causing hyperkalemia • Impaired release of renin: NSAIDs, Beta blockers, Cyclosporine, tacrolimus, Diabetes, Elderly •
Drugs causing hyperkalemia ... Beta blockers, Cyclosporine ... Drospirenone #Drugs #hyperkalemia
Mechanisms of Drug-Induced Hyperkalemia • Direct renin inhibitor (Aliskiren) • Renin release inhibition (NSAIDs, Beta-Blockers)
of Drug-Induced Hyperkalemia ... Inhibitors (Tacrolimus, Cyclosporine ... MunerMohamed1 #hyperkalemia
Drugs that Impair Renal Potassium Excretion Decreased ENaC channel function: Amiloride, Triamterene, Pentamidine Decreased Aldosterone Synthesis: Heparin,
Receptor Function: Cyclosporine ... happypillsrx/ #Hyperkalemia
Causes of Hyperkalemia Pseudohyperkalemia - Tourniquet use - Hemolysis (in vitro) - Leukocytosis - Thrombocytosis Intra- to extracellular
Causes of Hyperkalemia ... intoxication - Hyperkalemic ... receptor blockers, cyclosporine ... acidosis) #Hyperkalemia
Drugs associated with hypokalemia and hypomagnesemia Hypokalemia - Shift from extracellular fluid to intracellular fluid compartment -
associated with hypokalemia ... hypomagnesemia Hypokalemia ... Calcineurin inhibitors (cyclosporine ... panitumumab) #Drugs #hypokalemia
Hypomagnesemia - Differential Diagnosis Renal Causes of Hypomagnesemia - Familial: Bartter syndrome and Gitelman syndrome, Isolated recessive hypomagnesemia,
cisplatin, Tacrolimus, cyclosporine ... pentamidine), Hypercalcemia
Hyperuricemia - Differential Diagnosis Algorithm Primary - Over-production • Increased turnover of nucleotides Primary
Sarcoidosis • Hypercalcemia ... inhibitors • Cyclosporine
Hyperuricemia: Pathogenesis and Complications - Hypercalcemia (due to diseases like Sarcoidosis and Hyperparathyroidism) -> Accumulation of
Complications - Hypercalcemia ... ACE-inhibitors, Cyclosporine
Causes of Hyperkalemia l. Pseudohyperkalemia A Cellular efflux; thrombocytosis, erythrocytosis, leukocytosis, in vitro hemolysis B.
Causes of Hyperkalemia ... Hyperkalemic periodic ... axis; T risk of hyperkalemia ... inhibitors, ß-blockers, cyclosporine ... antiphospholipid syndrome #Hyperkalemia
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