41 results
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Cold Agglutinin ... Cold Agglutinins ... Diagnosis: • hemolytic ... sensitize red blood cells ... #hematology #diagnosis
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table

Warm AIHA (48-70%)
Cold AHA (16-32%)
 • Donath-Landsteiner HA (paroxysmal
AIHA (48-70%) Cold ... HA (paroxysmal cold ... hemoglobinuria) • Cold ... Agglutinin Disease ... #Table #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Autoimmune (AIHA)"Cold ... (e.g. primary cold ... #differential #diagnosis ... #hematology #anemia
Chronic Obstructive Pulmonary Disease (COPD)
 • COPD Definition
 • Role of PFTs
 • COPD Classification and
Disease (COPD) ... • COPD Definition ... Role of PFTs • COPD ... #Disease #COPD ... #diagnosis #management
Expected DAT Results in Autoimmune Hemolysis
DAT Negative Hemolysis
 • DAT Poly ( - ), IgG (
in Autoimmune Hemolysis ... , C3d ( +/- ) Cold ... agglutinin disease ... ) Paroxysmal cold ... #hematology #diagnosis
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
- Differential Diagnosis ... Algorithm • Sickle cells ... Agglutination - Cold ... #Differential #Diagnosis ... Algorithm #workup #hematology
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Cell Agglutinate: Cold ... autoimmune hemolytic ... anemia, Paroxysmal cold ... #differential #diagnosis ... #hematology #microscopy
Causes of Pulmonary Hypertension - Differential Diagnosis Algorithm
Pulmonary Arterial Hypertension
 • Idiopathic
 • Associated with:
Causes of Pulmonary ... - Differential Diagnosis ... Algorithm Pulmonary ... Hypoxemia: • COPD ... Miscellaneous: • Hematologic
Cold Urticaria
Prevalence - 0.05% in the population
Disease onset - Mostly 2nd to 4th decades of life
Causes
Cold Urticaria Prevalence ... skin contact with cold ... minutes after the cold ... 10.1111/all.14674 #Cold ... #rheumatology #
Lesions of the Spinal cord - Spinal Cord Syndromes

Spinal cord lesions can result in permanent neurologic
result in permanent neurologic ... deficiency - Syrinx ... Lower motor neuron symptoms ... #differential #diagnosis ... #neurology