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diagnosis differential management hematology rheumatology disease sclerosis agglutinin amyotrophic anemia apml behcet bilaterality brownsequard cancer cauda caudaequina causes cold cryofibrinogenemia
Lesions of the Spinal cord - Spinal Cord Syndromes Spinal cord lesions can result in permanent neurologic
- Spinal Cord Syndromes ... result in permanent neurologic ... deficiency - Syrinx ... Lower motor neuron symptoms ... Upper motor neuron symptoms
Principal patterns of loss of sensation. (a) Thalamic lesion: sensory loss throughout opposite side (rare).
(c) Central cord ... Hemisection of cord ... /unilateral cord ... Brown—Séquard syndrome ... (e) Transverse cord
Oncologic Emergencies - Differential Diagnosis Framework HEMATOLOGIC ONCOLOGIC EMERGENCIES: Hyperviscosity Syndrome: • Spontaneous bleeding • Shortness of breath
Hyperviscosity Syndrome ... of breath • Neurologic ... neutrophil count < 500 cells ... Epidural Spinal Cord ... : Tumor Lysis Syndrome
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin ... Cold Agglutinins ... Agglutinin Syndrome ... Disorders Such As ... sensitize red blood cells
Neurological Manifestations of Tuberculosis Spinal Arachnoiditis & Polyradiculopathy: • Subacute onset of limb weakness, bladder/bowel dysfunction, muscle
meninges in spinal cord ... nerve roots Spinal Cord ... Reconstitution Inflammatory Syndrome ... lymphadenopathy, pulmonary ... Children with pulmonary
Prader-Willi Syndrome: Pathogenesis and clinical findings • Maternal uniparental disomy: inheriting 2 copies of maternal chromosome
: inheriting 2 copies ... Loss of parental copy ... Signs/Symptoms ... , sleep apnea, cor ... pulmonale #PraderWilli
Cauda Equina Syndrome Overview Cauda Equina Syndrome: • Prevalence: 1:33,000-100,000 ppl/yr • Incidence: 1.5-3.4 million ppl/yr •
spine L1-L5 Symptoms ... ‘red flag’ symptoms ... Diagnosis: • Spinal cord ... spondylitis • Tethered cord ... diagnosis #causes #neurology
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
Cryofibrinogen is a cold ... - Albumin - Cold ... Cryofibrinogenemia Symptoms ... may include: • Cold ... Antiphospholipid syndrome
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
skin injury) • Neurologic ... matter, spinal cord ... meningitis), MCC CNS symptoms ... Medium and large also ... management #signs #symptoms
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Release from blast cells ... Imaging: CXR- pulmonary ... Diagnosis: >3 symptoms ... management #hematology #oncology
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