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diagnosis liver differential transaminitis dili laboratory acute alkphos arthritis astalt bilirubin causes disease drug druginduced function gastroenterology hepatocellular idiosyncratic induced
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Liver Function Tests ... Cirrhosis • Chronic ... Viral Hepatitis ... Drug-induced liver injury ... #Diagnosis #hepatology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver Injury ... 5-10x normal - Chronic ... Patterns #Liver #Injury ... #hepatology #LFTs ... #differential #diagnosis
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
→ liver test abnormalities ... • Infections: Hepatitis ... #hepatology #algorithm ... Transaminitis #LFTs ... #hepatitis
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
of Acute Liver Injury ... - Differential Diagnosis ... Ascariasis, Choledochal Cyst ... Causes #Acute #algorithm ... #hepatology
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism AST and ALT: • AST: liver
Liver Chemistry ... Tests - AST, ALT ... AlkPhos #Bilirubin #Hepatology ... Pathophysiology #Diagnosis ... #LFTs
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... : > 3 • Chronic ... Hemolysis #liver #chemistry ... #diagnosis #differential ... #Hepatology #transaminitis
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... presentation • Chronic ... - ongoing ↑ LFTs ... gastroenterology #algorithm ... gastroenterology #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
DILI) - Stepwise Diagnosis ... Algorithm DILI ... hepatitis fibrosis ... #Diagnosis #Algorithm ... #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Algorithm Vascular ... Ascariasis, Choledochal cyst ... extrahepatic source - Tests ... #diagnosis #algorithm ... #hepatology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
IgM) levels • Hepatitis ... for Chronic Polyarthritis ... (LFTs) and a serum ... (to support a diagnosis ... arthritis) • Hepatitis
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