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Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
pro-inflammatory cytokines ... hemophagocytosis and cytokine ... syndromes Clinical ... is the main clinical ... - Nonremitting fever
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
: Overwhelming clinical ... activation and cytokine ... following: • Fever
Renal Cell Carcinoma (RCC) - Diagnosis and Management Summary Clinical features - Classic triad (flank pain, hematuria,
Management Summary Clinical ... night sweats, fever ... ), Recombinant cytokines
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
pro-inflammatory cytokines ... accumulation of clinical ... Assessment • Clinical ... : fever +++, hepatosplenomegaly
Sarcoidosis - Diagnosis and Management Summary Epidemiology 1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
Epithelioid cells → cytokines ... renal failure Clinical ... General: fever, ... syndrome: ACUTE, fever ... presentation with fever
Hypothermia in Sepsis - Pathophysiology • 20% of septic pts → HYPOTHERMIA • Increased mortality 62%
proinflammatory cytokines ... anti-inflammatory cytokine
Giant Cell (Temporal) Arteritis: Pathogenesis and investigations Risk Factors: - Unclear environmental triggers (may be viral, not
alter inflammatory cytokine ... GCA is almost never ... /Symptoms: - Fever
Faget Sign - Pulse-Temperature Dissociation Causes of Relative Bradycardia • Infectious Causes: Legionella, Psittacosis, Q fever, Typhoid
Psittacosis, Q fever ... , Typhoid fever, ... , Dengue fever, ... Mountain spotted fever ... , Drug fever
Fever Patterns - Differential Diagnosis Framework Continuous Fever: Temp > 38°C with only 1 degree fluctuation in 24
Fever Patterns - ... Continuous Fever ... (Step ladder: fever ... Intermittent Fever ... or no fever •
Faget's Sign & Liebermeister's Rule Pulse-Temperature Dissociation EVERY 1 F RISE IN TEMPERATURE -> HR INCREASES 8-10 BPM INFECTIOUS
Psittacosis • Q Fever ... • Typhoid Fever ... • Drug Fever ... CLINICAL UTILITY ... Typhoid Fever (S
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