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Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
pro-inflammatory cytokines ... hemophagocytosis and cytokine ... Diagnosis #Management #Hematology ... #Rheumatology
Anemia of Chronic Disease - Pathophysiology One theory to explain why "anemia of chronic disease" exists: The inflammatory
The inflammatory cytokine ... chronic #disease #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
activation and cytokine ... management #treatment #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Pathophysiology: • Cytokine ... diagnosis #management #hematology
Hypothermia in Sepsis - Pathophysiology • 20% of septic pts → HYPOTHERMIA • Increased mortality 62%
proinflammatory cytokines ... anti-inflammatory cytokine
Cutaneous Manifestations of Monoclonal Gammopathy • Extravascular lg Deposits: Systemic amyloidosis, Nodular amyloidosis, Macroglobulinoderma, Follicular hyperkeratotic
Xanthomatosis • Cytokine ... manifestations #dermatology
Pathophysiology of Hypocomplementemic Urticarial Vasculitis C1q/anti-C1q antibiody -> Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Anaphylatoxins, Chemokines, Cytokines ... Pathophysiology #Rheumatology
Immune Reactions and Immunosuppressant Drugs Glucocorticoids - Inhibition of cytokine synthesis, e.g., IL-1, IL-2 Muromonab-CD3 - Monoclonal antibody Calcineurin
Inhibition of cytokine ... Inhibition of cytokine
Systemic Lupus Erythematosus (SLE): Pathogenesis • Genetic factors (Mutations in HLA- DR2/HLA-DR3 genes, complement genes, cytokine
complement genes, cytokine ... of inflammatory cytokines
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm Sequestration: • Splenomegaly Marrow Infiltration: • Hematologic and non-hematologic
Infiltration: • Hematologic ... and non-hematologic ... Algorithm #Causes #Hematology
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