259 results
Immune Reactions and Immunosuppressant Drugs

Glucocorticoids - Inhibition of cytokine synthesis, e.g., IL-1, IL-2
Muromonab-CD3 - Monoclonal antibody
Calcineurin
Immune Reactions ... Inhibition of cytokine ... Inhibition of cytokine
Eosinophils (Eos) and hypereosinophilia (HE)
Caused by eosinophilopoietic cytokines
Common causes:
 - Drug reaction
 - Helminth infection
 -
eosinophilopoietic cytokines ... causes: - Drug reaction ... infection - Allergic reaction
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
hypersensitivity reactions ... Acute transfusion reaction ... release inflammatory cytokines ... hypersensitivity #reactions
Anaphylaxis: Pathogenesis
Anaphylaxis is a Type 1 hypersensitivity reaction
While the primary mechanism of anaphylaxis is mast cell
hypersensitivity reaction ... mediators (e.g. cytokines
Blood Transfusion Reactions

Immune Mediated:
 • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Blood Transfusion Reactions ... common immune reaction ... accumulated inflammatory cytokines ... once had another reaction ... • Allergic reaction
Kounis Syndrome

Acute coronary syndrome (symptoms such as chest pain relating to reduced blood flow to the
by an allergic reaction ... strong immune reaction ... of inflammatory cytokines ... agents from the reaction
Blood Product Transfusions One Pager Summary
Type and screen - determines blood type and detects in recipient
platelets Transfusion Reactions ... common immune reaction ... accumulated inflammatory cytokines ... once had another reaction ... - Allergic reaction
Anti-IL6 Agents (Tocilizumab, Siltuximab) in COVID19

IL-6 activates T cells and macrophages, among other cell types (see
cell types (see “Cytokine ... 22% - Infusion reaction
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
cells secrete cytokines ... Allergy #Diagnosis #Reactions
Hypothermia in Sepsis - Pathophysiology
 • 20% of septic pts → HYPOTHERMIA
 • Increased mortality 62%
proinflammatory cytokines ... anti-inflammatory cytokine