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Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation Syndrome ... pro-inflammatory cytokines ... hemophagocytosis and cytokine ... Periodic fever syndromes ... #Diagnosis #Management
Streptococcal Toxic Shock Syndrome (STSS) Complication of invasive GAS disease characterized by shock & MOF → occurs
Streptococcal Toxic Shock Syndrome ... of inflammatory cytokines ... #Toxic #Shock #Syndrome ... STSS #treatment #management
Anti-IL6 Agents (Tocilizumab, Siltuximab) in COVID19 IL-6 activates T cells and macrophages, among other cell types (see
cell types (see “Cytokine ... Activation Syndrome ... #Pharmacology #Management
KSHV Inflammatory Cytokine Syndrome (KICS) Working Case Definition for KICS: Requires at least 2 clinical manifestations (from
KSHV Inflammatory Cytokine ... Syndrome (KICS) ... #Inflammatory #Cytokine ... #Syndrome #Kaposi ... #diagnosis #management
Fever vs Hyperthermia Fever: • Regulated in the hypothalamic thermoregulatory center • "Set point" raised by prostaglandin
Endotoxins, Toxins, Cytokines ... Neuroleptic malignant syndrome ... ; Serotonin syndrome ... comparison #diagnosis #management
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Pathophysiology: • Cytokine ... Differentiation #Syndrome ... APML #diagnosis #management
Renal Cell Carcinoma (RCC) - Diagnosis and Management Summary Clinical features - Classic triad (flank pain, hematuria,
Diagnosis and Management ... Budd Chiari syndrome ... ), Recombinant cytokines ... RCC #Diagnosis #Management
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... activation and cytokine ... Lymphohistiocytosis #diagnosis #management
Sarcoidosis - Diagnosis and Management Summary Epidemiology 1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
Diagnosis and Management ... Epithelioid cells → cytokines ... Specific sarcoidosis syndromes ... • Heerfordt syndrome ... Sarcoidosis #Diagnosis #Management
Hypothermia in Sepsis - Pathophysiology • 20% of septic pts → HYPOTHERMIA • Increased mortality 62%
proinflammatory cytokines ... anti-inflammatory cytokine
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