2733 results
Streptococcal Toxic Shock Syndrome (STSS)
Complication of invasive GAS disease characterized by shock & MOF → occurs
of invasive GAS disease ... of inflammatory cytokines ... necrosis STSS Treatment ... BIDMC Infectious Diseases ... Syndrome #STSS #treatment
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
highly inflammatory disease ... pro-inflammatory cytokines ... hemophagocytosis and cytokine ... of underlying disease ... Treatment: • Corticosteroids
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
pro-inflammatory cytokines ... • Autoimmune diseases ... Adult-onset Still disease ... Unknown cause Treatment ... diagnosis #management #treatment
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
activation and cytokine ... age, however the disease ... • Bicytopenia Treatment ... diagnosis #management #treatment
Renal Cell Carcinoma (RCC) - Diagnosis and Management Summary
Clinical features - Classic triad (flank pain, hematuria,
locally advanced disease ... of metastatic disease ... Imaging and Treatment ... of metastatic disease ... ), Recombinant cytokines
A quick infographic on various pearls about atopic dermatitis, a disease with an increasing burden on
dermatitis, a disease ... recommendations, treatments ... inflammatory skin disease ... This disease imposes ... skin barrier, cytokines
Hypothermia in Sepsis - Pathophysiology
 • 20% of septic pts → HYPOTHERMIA
 • Increased mortality 62%
proinflammatory cytokines ... anti-inflammatory cytokine
Eosinophils (Eos) and hypereosinophilia (HE)
Caused by eosinophilopoietic cytokines
Common causes:
 - Drug reaction
 - Helminth infection
 -
eosinophilopoietic cytokines ... reaction - Atopic disease ... lymphomas, Hodgkin disease ... , IgG4-related disease ... inflammatory bowel diseases
Cutaneous Manifestations of Monoclonal Gammopathy
 • Extravascular lg Deposits: Systemic amyloidosis, Nodular amyloidosis, Macroglobulinoderma, Follicular hyperkeratotic
Cold agglutinin disease ... Xanthomatosis • Cytokine
Immune Reactions and Immunosuppressant Drugs

Glucocorticoids - Inhibition of cytokine synthesis, e.g., IL-1, IL-2
Muromonab-CD3 - Monoclonal antibody
Calcineurin
Inhibition of cytokine ... Inhibition of cytokine