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diagnosis differential hematology intravascular coagulation hemolysis rash aptt bruising canimorsus capnocytophaga clinical cryofibrinogenemia disseminated hemolytic hemorrhage management obgyn obstetrics pediatrics
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... Algorithm Extravascular ... Drug-induced AIHA - Abnormal ... • MAHA (TTP, DIC ... #Algorithm #Causes
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Causes Intravascular ... coagulation (DIC ... thrombocytopenic purpura ... #diagnosis #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Petechiae • Purpura ... Hemorrhagic bullae • Purpura ... Treat primary cause ... #Coagulation #diagnosis ... #causes #treatment
Causes of Post-Partum Hemorrhage - Differential Diagnosis Algorithm Blood Loss: >500mL post vaginal delivery OR >1000 mL
Causes of Post-Partum ... Algorithm Blood ... succenturiate lobe • Abnormal ... coagulation (DIC ... #Algorithm #Causes
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Causes of Petechial ... Algorithm Pinpoint ... fulminans - DIC ... #Algorithm #Causes ... #dermatology #physicalexam
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
Causes of Purpura ... - DIC (disseminated ... Platelet count normal ... #peds #pediatrics ... #diagnosis #differential
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
Thrombocytopenic Purpura ... result in severe anemia ... reflection of intravascular ... immune hemolytic anemia ... #Workup #Hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... Prolonged Activated Partial ... coagulation (DIC ... #diagnosis #differential ... #hematology #coagulation
Capnocytophaga Canimorsus Skin Rash 40 M presents w/ N, V, severe epigastric pain. SHx: smoker, drinks 18
Bandemia, AKI. ... +purpuric rash → ... inflammation persist → DIC ... the key to the diagnosis ... Canimorsus #Skin #Rash #dermatology
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
cooled from the normal ... Skin necrosis • Purpura ... Cryofibrinogenemia Diagnosis ... cryoglobulins • Negative causes ... skin necrosis • DIC
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