1186 results
Drug-Induced Liver Injury - Pathophysiology
Indirect
Idiosyncratic
Direct

BWH Medicine Chiefs @BrighamChiefs

#DILI #DrugInduced #Liver #Injury #Pathophysiology #hepatology
Liver Injury - Pathophysiology ... BrighamChiefs #DILI ... Liver #Injury #Pathophysiology
Hypothermia in Sepsis - Pathophysiology
 • 20% of septic pts → HYPOTHERMIA
 • Increased mortality 62%
Hypothermia in Sepsis - Pathophysiology ... cytokines ↓TNF-α, ↓IL ... -6, ↓IL-1 3. ... cytokine response ↑IL ... Hypothermia #sepsis #pathophysiology
Immune Reactions and Immunosuppressant Drugs

Glucocorticoids - Inhibition of cytokine synthesis, e.g., IL-1, IL-2
Muromonab-CD3 - Monoclonal antibody
Calcineurin
synthesis, e.g., IL ... -1, IL-2 Muromonab-CD3 ... Basiliximab - IL ... Suppression of IL ... #Pharmacology #Pathophysiology
Fig. 1 Pathophysiology of septic myocardial dysfunction. IL interleukin, iNOS induced nitric oxide synthase, PMN polymorphonuclear
Fig. 1 Pathophysiology ... IL interleukin, ... necrosis factor #Pathophysiology
The biotrauma hypothesis of ventilator-induced lung injury. IL = interleukin; PEEP = positive end-expiratory pressure; Pplat
IL = interleukin ... #Pathophysiology
Diabetes Pathophysiology and Medication Targets

The ominous octet is one concept that summarizes the different pathophysiologic pathways
Diabetes Pathophysiology ... the different pathophysiologic ... #Diabetes #Pathophysiology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
Intravascular Coagulation (DIC ... protein C and S Pathophysiology ... Manifestations of DIC ... MAHA: TTP/HUS > DIC ... increase > 100mg/dL
Psoriatic Arthritis: Pathogenesis and Clinical findings

In tendons and connective tissues:
 • Enthesitis  - Pain/tenderness over
pitting, ridging, oil ... Arthritis of DIP ... PsoriaticArthritis #pathophysiology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
Induced Lupus (DIL ... rash is rare in DIL ... , SCLE-DIL (terbinafine ... for cutaneous DIL ... for cutaneous-DIL
Classification of COVID-19 Disease States and Potential Therapeutic Targets

Viral Response Phase -> Host Inflammatory Response Phase
Stage
immunoglobulin, IL ... -6 inhibitors, IL ... Classification #Diagnosis #Pathophysiology