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Drug-Induced Liver Injury - Pathophysiology Indirect Idiosyncratic Direct BWH Medicine Chiefs @BrighamChiefs #DILI #DrugInduced #Liver #Injury #Pathophysiology #hepatology
Liver Injury - Pathophysiology ... BrighamChiefs #DILI ... Liver #Injury #Pathophysiology
Drugs and Classes Associated with DILI and Type of Liver Injury #Medications #Differential #DrugInduced #LiverInjury #Hepatology #Pharmacology
Associated with DILI ... Pharmacology #Causes #DILI
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 Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Liver Injury (DILI ... ) DILI Types: ... disease 6-9 mo after DILI ... • Cholestatic DILI ... EmoryGastroHep #DILI
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Liver Injury (DILI ... Diagnosis Algorithm DILI ... injury, Previous DILI ... hepatitis #DILI
HFNC compared to NIV HFNC: - Comfort - Higher comfort Eating, drinking and speaking less impaired -
preload - P-SILI ... /VILI - Lower risk
Amiodarone-Induced Lung Iniurv (AILI) - Timeline Hours to days (peri-procedurally): ARDS Days to months: DAH Weeks: Eosinophilic pneumonia Weeks to
Amiodarone-Induced Lung Iniurv (AILI ... Induced #LungIniurv #AILI
Elevated Transaminases / Transaminitis - Differential Diagnosis • Infectious: HAV, HCV, HEV, EBV, HSV, CMV •
• Iatrogenic: DILI
Diabetes Pathophysiology and Medication Targets The ominous octet is one concept that summarizes the different pathophysiologic pathways
Diabetes Pathophysiology ... the different pathophysiologic ... #Diabetes #Pathophysiology
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Pregnancy (AFLP) Pathophysiology ... 10x ULN), ↑Tbili/Dbili ... diagnosis #management #pathophysiology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
(>1000): • DILI
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