10 results
Oral anticoagulant dosing and bridging for VTE

- Dr. Joseph Shatzel @Clotmaster 

#VTE #DOAC #Bridging #Dosing #Oral
Oral anticoagulant ... #DOAC #Bridging ... Anticoagulant #Anticoagulation ... #Dabigatran #Apixaban ... #Rivaroxaban #Edoxaban
Patient risk stratification algorithm for the treatment of cancer-associated thrombosis.

Currently, edoxaban and rivaroxaban are the only
for the treatment ... and rivaroxaban ... controlled trial ... #DOAC #VTE #Malignancy ... #Anticoagulation
Pharmacokinetic Characteristics and Primary Routes of Clearance of Oral Anticoagulant Agents

Warfarin - 100% Hepatic, 0% Renal
Apixaban
Anticoagulant Agents ... Hepatic, 25% Renal Dabigatran ... Hepatic, 80% Renal Edoxaban ... #Pharmacology # ... #anticoagulation
DOAC: Cheat Sheet - Atrial Fibrillation, VTE Prophylaxis, VTE and Renal Dosing

Renal Dosing:
Apixaban (25% renal clearance):
DOAC: Cheat Sheet ... - Atrial Fibrillation ... OralAnticoagulant #Anticoagulation ... #Hematology #Pharmacology ... #Dabigatran #Edoxaban
Heparin, Fondaparinux, and Novel Oral Anticoagulants - Pathophysiology

Anticoagulation with parenteral (intravenous or subcutaneous) and oral anticoagulants
the mainstay of VTE ... accelerates the bridging ... : A new oral anticoagulant ... Heparins #LMWH #UFH #DOAC ... #Dabigatran #Apixaban
Choice of anticoagulant for treatment of pulmonary embolism
 • Malignancy - LMWH
 • To avoid parenteral
for treatment of ... • Once a day oral ... ; edoxaban; VKA ... #vte #anticoagulation ... #pharmacology
DOAC Reversal
Emergency surgery or urgent procedure
Stop anticoagulant treatment; volume resuscitation and transfusion as needed
Antidotes:
 • Apixaban,
treatment; volume ... : • Apixaban, Edoxaban ... or Rivaroxaban ... modified factor Xa • Dabigatran ... #Oral #anticoagulant
Perioperative Management of DOACs
Problem:
 ✖ Each year approximately 250,000 patients on chronic anticoagulation in North America
direct acting oral ... of Therapy • Dabigatran ... ) • Apixaban, Edoxaban ... , Rivaroxaban (anti-XA ... #pharmacology #
Treatment algorithm for VTE in Malignancy

(A) Suggested treatment algorithm for symptomatic and incidental DVT or PE
Treatment algorithm ... **Edoxaban is initiated ... DOAC, direct oral ... #DOAC #VTE #Malignancy ... #Anticoagulation
Xa Inhibitors - Apixaban and Rivaroxaban 
Oral Xa inhibitors are recommended by CHEST as first-line for
Oral Xa inhibitors ... treatment or Atrial ... Fibrillation requiring anticoagulation ... indications and edoxaban ... #Dosing #Pharmacology