21 results
THE LIMPING OR NON-WEIGHT BEARING CHILD PATHWAY

RED FLAGS - In all cases there are specific
markers which
NON-WEIGHT BEARING CHILD ... RED FLAGS - In all ... Algorithm #Pathway #Child ... #Peds #Pediatrics ... #Diagnosis
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
ALP enzyme- Discovered ... in 1923 Low ALP ... 1948 by Rathbun ALP ... , ↓ALP → Low ... Hyophosphatasia #hepatology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
Leukemias Overview: ALL ... age • 75% of ALL ... distinctive primary granules ... #Leukemia #Hematology ... #Oncology #Diagnosis
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
Alkaline Phosphatase (ALP ... Algorithm ALP ... - Increased ALP ... Surgical consult ALP ... #Phosphatase #ALP
Thrombotic Microangiopathy - TMAs
1. Not all MAHAs are due to TMAs but (almost) all TMAs cause
Not all MAHAs are ... TMAs but (almost) all ... /o significant renal ... Microangiopathy #TMAs #hematology ... #diagnosis #ttp
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
: • Defect in fetal ... , ↑Tbili/Dbili/AP ... ) Differential Diagnosis ... Liver #Pregnancy #hepatology ... obstetrics #obgyn #diagnosis
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Incidence: common in APL ... opacities • Diagnosis ... Anaphylaxis, Acute Renal ... unless severe APLS ... #hematology #oncology
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis

Neurologic-Centered:
 (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
- Differential Diagnosis ... Features: POEMS, AL ... Cryoglobulinemia Renal-centered ... #Differential #Diagnosis ... #hematology #oncology
A quick infographic on various pearls about atopic dermatitis, a disease with an increasing burden on
Wigley AM, et al ... Chinellato I, Boner AL ... A, Tesch F, et al ... , Agerbo E, et al ... Mulick A, Yu AM, et al
Spontaneous Bacterial Peritonitis
DIAGNOSTICS
Paracentesis: 
 • Calculate absolute PMN count (total WBC x PMN %)
 • Correct
Bacterial Peritonitis DIAGNOSTICS ... Recommended for all ... recommended for all ... liver disease (Child-Pugh ... bilirubin 3) or renal