53 results
Acute promyelocytic leukemia (blood). Typical morphologic features are bilobed ("butterfly") nuclei with dispersed chromatin, subtle to
overt cytoplasmic granules ... I see all of these ... promyelocytic #leukemia #APL ... #APML #Pathology ... #Hematology #Clinical
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Bone marrow disease ... deficiency • Liver disease ... Von Willebrand disease ... - PNH - APLS ... Differential #Diagnosis #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
PT, aPTT(liver disease ... bypass), LFT (liver disease ... not required in all ... or if a primary hematologic ... Causes #Workup #hematology
THE LIMPING OR NON-WEIGHT BEARING CHILD PATHWAY

RED FLAGS - In all cases there are specific
markers which
RED FLAGS - In all ... suspicion of severe disease ... - Sickle cell disease ... Rheumatology ... Pathway #Child #Peds
Clinical Classification of Pulmonary Hypertension

1. Pulmonary arterial hypertension from pulmonary vasculopathy
Idiopathic pulmonary arterial hypertension
Heritable gene mutations
Clinical Classification ... multifactorial mechanisms Hematologic ... disorders, lenectomy ... Systemic disorders ... , thyroid disorders
Basophilia - Differential Diagnosis Framework

Basophils < 1% of the total white blood cell count
Basophils function similarly
histamine in their granules ... Myeloproliferative Disorders ... Colitis and Crohn’s Disease ... Diagnosis #causes #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
Leukemias Overview: ALL ... , CML, AML, APML ... extramedullary disease ... distinctive primary granules ... #Leukemia #Hematology
Pyoderma Gangrenosum: Autoimmune disorder resulting in a vasculitis which causes slowly progressive 
ulceration of the skin.
Gangrenosum: Autoimmune disorder ... number of systemic diseases ... UCSD Catalog of Clinical ... Images #Clinical ... #Photo #Dermatology
Von Willebrand Disease - Most common inherited bleeding disorder 
Clinical 
 • Easy bruising 
 •
Von Willebrand Disease ... inherited bleeding disorder ... Clinical • ... VonWillebrand #Disease ... #Diagnosis #Hematology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE) Clinical ... Headache, Movement disorders ... , Seizure disorders ... Cerebrovascular Disease ... (for secondary APS