38 results
Algorithm for workup of thrombocytopenia based on observation of the peripheral blood film. 
TTP/HUS indicates thrombotic
for workup of thrombocytopenia ... purpura/hemolytic ... uremic syndrome ... How to approach thrombocytopenia ... , Hematology 2012
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... ) - HELLP syndrome ... microangiopathy: Thrombotic thrombocytopenic ... uremic syndrome ... #anemia
Causes of Hemolytic Anemia - Differential Diagnosis
Inherited
 • Membrane
 • Internal
    - Hemoglobin
Causes of Hemolytic ... Anemia - Differential ... - Antibody/DAT ... - Complement/DAT ... Diagnosis #Causes #hematology
Differential diagnosis of schistocytes / fragmentation hemolysis:
 • Thrombotic microangiopathies (TMA)
    - TTP
syndrome (ST-HUS ... anemia" • HELLP ... syndrome • Catastrophic ... differential #diagnosis #hematology ... #hemolysis
Autoimmune Hemolytic Anemia (AIHA) Pathophysiology - Warm vs Cold AIHA
Warm AIHA:
 - 70%; IgG mediated
 -
Autoimmune Hemolytic ... Anemia (AIHA) Pathophysiology ... IgG mediated - DAT ... IgM mediated - DAT ... #diagnosis #hematology
Red Blood Cell (RBC) Morphology Atlas
 • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Myelodysplastic syndrome ... spherocytosis, Hemolytic ... uremic syndrome ... Thrombotic idiopathic thrombocytopenia ... #differential #hematology
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table

Warm AIHA (48-70%)
Cold AHA (16-32%)
 • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic ... Anemia (AIHA) - ... Mixed-type AIHA (7-8%) DAT-negative ... #Anemia #AIHA # ... Diagnosis #Table #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Schistocytes, thrombocytopenia ... ARUPConsult @ARUPLabs #Hemolytic ... #Anemia #Differential ... Algorithm #workup #hematology
Schistocytes - The arrows point to schistocytes which are fragmented red blood cells. Also called schizocytes,
anemias, especially ... anemia in which ... usually also have thrombocytopenia ... - uremic syndromes ... and thrombotic thrombocytopenic
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
Causes of Thrombocytopenia ... Megakaryopoiesis • Aplastic Anemia ... Non-lmmune: • HELLP Syndrome ... Heart Valve) #Thrombocytopenia ... Algorithm #Causes #Hematology