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diagnosis hematology algorithm causes thrombocytosis management oncology cll erythematosus framework gap globulin hemodialysis hypokalemia hyponatremia hypophosphatemia lupus lymphocytic mds myelodysplasia
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Thrombocytosis - Differential ... malignancies • Anemia ... hemorrhage) • Chronic ... Myelodysplastic syndrome ... myeloid leukemia
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Thrombocytosis - Differential ... Myelogenous Leukemia ... : • Acute or Chronic ... effect following treatment ... Iron deficiency anemia
Workup for Hypophosphatemia - Differential Diagnosis Framework Rule out spurious hypophosphatemia: paraproteinemia, acute leukemia Measure Urine Fractional Excretion
Workup for Hypophosphatemia ... - Differential ... paraproteinemia, acute leukemia ... Malabsorption, Chronic ... #phosphate #nephrology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... • Neutropenia, anemia ... microglobulin Treatment ... #CLL #Chronic ... #diagnosis #workup
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
for workup, including ... hemolysis, deficiency anemia ... Rebound effect from treatment ... Kawasaki, Nephrotic syndrome ... • Infections: Chronic
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... Marrow Failure • Chronic ... Myelogenous Leukemia ... Workup: • Complete ... blood count with differential
Causes of Peripheral Weakness without Sensory Changes - Differential Diagnosis Algorithm No Objective Weakness • Cardio-pulmonary disease
Cardio-pulmonary disease • Anemia ... • Chronic Infection ... Lambert-Eaton Myasthenic Syndrome ... involvement, elevated CK ... #Differential #
Causes of Hypokalemia Transcellular Shifts: - Alkalosis, Increased plasma insulin (treatment of diabetic ketoacidosis), ß-Adrenergic agonists, Hypokalemic
plasma insulin (treatment ... Hypomagnesemia, Acute leukemia ... megaloblastic anemia ... Hypokalemia #Causes #differential ... #diagnosis #nephrology
Hyponatremia - Diagnosis and Treatment Hyponatremia is usually caused by the inability to excrete water normally.
3 questions to work ... approach to the differential ... correction of chronic ... demyelination syndrome ... #management #nephrology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... Valvular disorders • CAD ... lymphopenia, low PLT • Anemia ... with Lupus: • Chronic ... Hodgkin lymphoma and leukemia
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