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diagnosis erythematosus sle systemic cardiology ecg electrocardiogram equivalents pain stemi symptoms vasculitis arthritis autoantibodies autoimmune classification conditions extrarticular interpretation leukostasis
STEMI Equivalents on ECG • Conventional STEMI - Elevation of ST segment at (or 40-60 ms
V2 • Wellens sign ... pain • Wellens sign ... deviation) • Acute ischemia ... #EKG #diagnosis ... #differential #
Approach to ECGs - Ischemia MI = Biomarkers + ECG or echo/angiogram findings Pathologic Q - 1/3 height
infarct STEMI - J point ... Equivalents / Don't Miss Signs ... bigger than QRS - deWinter ... #ECG #EKG #diagnosis ... Interpretation #differential
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Features of Systemic Lupus ... (SLE) General: Fever ... phenomenon (20%) Joints ... erythematosus #signs ... symptoms #diagnosis #rheumatology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Malar rash 40% - Fever ... (aPL) 30-45% Differential ... autoantibodies #signs ... symptoms #mimickers #differential ... #rheumatology
Extra-articular and Other Conditions Associated with Joint Pain Eyes • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
Associated with Joint ... polychondritis, GPA • Ischemic ... disease, Vasculitis (e.g ... #pain #differential ... #diagnosis #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
weight loss, and fever ... permanent alopecia Differential ... . hematologic) ... Arthritis: • Joint ... Erythematosus #Diagnosis #Rheumatology
Approach to Joint Pain - Arthritis Differential Diagnosis Framework Inflammatory Versus Noninflammatory Pain • Is it inflammatory
Pain - Arthritis Differential ... noninflammatory Signs ... • Rheumatic fever ... #pain #Differential ... Diagnosis #MSK #rheumatology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
- 80% have fever ... AKI, acute limb ischemia ... WBC >100k, + lab signs ... unless worrisome EKG ... diagnosis #management #hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
: • Purpura, ischemic ... vesicular eruption - Joints ... such as systemic lupus ... purpura: strong sign ... #diagnosis #rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Vasculitis - Differential ... purpura: Strong sign ... vesicular eruption • Joints ... Palpable purpura, joint ... #Diagnosis #Rheumatology
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