14 results
Graves’ Disease: Pathogenesis and Clinical Findings
B & T lymphocyte mediated autoimmunity attack TSH receptor -> Continuous
GravesDisease: ... the etiology Signs ... GravesDisease #pathophysiology ... #endocin #endocrinology ... #symptoms #signs
Cardiac Amyloid - Diagnosis, Signs, Symptoms and Management

Clinical Presentation
- exertional dyspnea
- peripheral edema
- exertional syncope
- peripheral
, Symptoms and Management ... despite hx HTN) EKG ... pseudoinfarct pattern (Q-waves ... - conduction disease ... #Symptoms #Cardiology
Approach to ECGs - Ischemia
MI = Biomarkers + ECG or echo/angiogram findings
Pathologic Q - 1/3 height
Approach to ECGs ... = Biomarkers + ECG ... Equivalents / Don't Miss Signs ... bigger than QRS - deWinter ... triple vessel disease
Primary Hyperthyroidism - Pathogenesis and Clinical Findings

Note: Although rare, gestational diseases can lead to thyrotoxicosis due
rare, gestational diseases ... excess secretion of hCG ... Signs/Symptoms: ... Hyperthyroidism #endocrinology ... #pathophysiology
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
activates lipolysis Signs ... /Symptoms: • GH ... tissue expansion (e.g ... #FeedbackLoop #endocrinology ... #pathophysiology
Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
share the same pathophysiology ... Cardiovascular disease ... Overproduction #diagnosis #signs ... #symptoms #endocrinology ... #pathophysiology
Primary Adrenal Insufficiency
Addison's Disease - Damage of the adrenal glands with lack of cortisol, androgens and
Insufficiency Addison's Disease ... Lymphoma Metastatic Disease ... Administer 250 mcg ... #endocrinology ... #diagnosis #signs
Hyperthyroidism Overview

Clinical Manifestation of Hyperthyroidism:
 • Fatigue
 • Weight loss
 • Heat intolerance
 • Depression, nervousness
diffuse goiter (Graves ... ' disease) • Thyrotoxicosis ... ' disease is suspected ... #differential #endocrinology ... #signs #symptoms
X-Linked Agammaglobulinemia: Pathogenesis and clinical findings
The epidemiology of this disease is 1/340,000 births and roughly double
epidemiology of this disease ... history of the disease ... Signs of immunodeficiency ... /Symptoms/Findings ... Agammaglobulinemia #XLinked #pathophysiology
Causes of Secondary Hypertension - Workup and Differential Diagnosis
Approach (when evaluation should be done):
1. Severe or
hypertension and signs ... renal bruit or signs ... Coarctation of aorta ... Vasculitis • Endocrinologic ... Renal parenchymal disease