88 results
Three Ds of Clinical Debriefing : Deactivation, Deconstruction and Dissemination 

- Dr. Ben Symon https://twitter.com/symon_ben

#Clinical #Debriefing
Ds of Clinical Debriefing ... : Deactivation, ... #Clinical #Debriefing ... #3Ds #DDDs #Deactivation
How dendritic cells (DCs) orchestrate adaptive immunity
1- Sensing of microbial and damage signals by DCs
2- Phenotypic
changes during DCs activation ... 3- DC are professional ... immunity #immunology #pathophysiology
Pathophysiology of Hypocomplementemic Urticarial Vasculitis

C1q/anti-C1q antibiody ->
Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology ... Complement Pathway Activation ... Vasculitis #HUV #Pathophysiology
Anaphylaxis: Pathogenesis
Anaphylaxis is a Type 1 hypersensitivity reaction
While the primary mechanism of anaphylaxis is mast cell
anaphylaxis is mast cell activation ... Inappropriate mast cell activation ... cells • ANS activation ... #Anaphylaxis #pathophysiology
Inflammatory mechanism of asthma. 
Airway epithelial cells exposed to activation stimuli, including allergens, viruses, and irritants,
cells exposed to activation ... dendritic cell (DC ... activate naive CD4 ... #asthma #pathophysiology
Acute Rheumatic Fever: Pathogenesis and Clinical Findings

Delayed autoimmune reaction
-> Molecular mimicry
-> GAS antigen cross-reacts with host
->
with host -> Activation ... auto-reactive B and CD ... RheumaticFever #pathophysiology
Autoimmune Gastritis - Pathophysiology

Anti-ParietaI Cell, CD4+ T Cells, Autoantibodies -> x Parietal Cells, x HCL, x
Autoimmune Gastritis - Pathophysiology ... Anti-ParietaI Cell, CD4 ... Autoimmune #Gastritis #Pathophysiology
Non-Infective Endocarditis - Pathophysiology
Non-infective Endocarditis Pathophysiology:
 • Valves usually undamaged - Etiology poorly understood but thought
Endocarditis - Pathophysiology ... Non-infective Endocarditis Pathophysiology ... Infective Endocarditis Pathophysiology ... forms and promotes activation ... NBTE #Marantic #pathophysiology
Type IV Hypersensitivity: Pathogenesis and clinical findings
Definition: Unique because it is entirely T-Cell mediated; exposure to
because T-Cell activation ... -> Particular CD4 ... Allergy #Immunology #pathophysiology
Tranexamic Acid: Mechanism of Action
 - TXA is an anti-fibrinolytic
 - TXA is a synthetic analog
fibrin → preventing activation ... Tranexamic #Acid #pathophysiology