405 results
Antiplatelet Conversion - Switching Between P2Y12 Inhibitors
Oral P2Y12 inhibitors vary in potency and pharmacokinetic and dynamic
Between P2Y12 Inhibitors ... Oral P2Y12 inhibitors ... Switching P2Y12 inhibitors ... - Escalation ... Ticagrelor - De-escalation
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
• Direct renin inhibitor ... Renin release inhibition ... of aldosterone inhibition ... • Calcineurin Inhibitors ... #hyperkalemia #differential
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
Differential Diagnosis ... direct thrombin inhibitors ... Inhibitors: Non ... specific inhibitor ... Causes #diagnosis #differential
Drugs associated with hypokalemia and hypomagnesemia

Hypokalemia
- Shift from extracellular fluid to intracellular fluid compartment
  -
Extrarenal Proton pump inhibitor ... Tyrosine kinase inhibitors ... - Calcineurin inhibitors ... #Medications #differential ... #diagnosis #nephrology
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Direct Xa inhibitors ... Specific inhibitors ... Specific inhibitors ... Inhibitors ... Causes #diagnosis #differential
Antiplatelet Conversion - Switching Between Oral P2Y12 Inhibitors
A, Switching between oral agents in the acute/early phase.
Between Oral P2Y12 Inhibitors ... patients who are deescalating ... *Consider de-escalation ... De-escalation from ... .117.031164 #P2Y12 #Inhibitor
Causes of HyperKalemia - Differential Diagnosis
Increased extracellular K+:
 • Tissue injury
 • Hemolysis
 • Rhabdomyolysis
 •
HyperKalemia - Differential ... Hypovolemia • RAAS inhibitor ... • Calcineurin inhibitor ... blockers - MCW Nephrology ... #HyperKalemia #Differential
Allopurinol and its active metabolite inhibit xanthine oxidase, the enzyme that converts hypoxanthine to xanthine and
active metabolite inhibit ... Inhibition of this ... druginformation #nephrology
How SGLT2 inhibitors block glucose reabsorption in proximal tubule and improve systemic glucose homeostasis:
https://www.ajkd.org/article/S0272-6386(18)30633-4/fulltext

#Pathophysiology #Mechanism #Nephrology
How SGLT2 inhibitors ... Pathophysiology #Mechanism #Nephrology ... #SLGT2 #Inhibitors
TNF-alpha Inhibitors

Dr. Ann Marie Kumfer @AnnKumfer

#TNFalpha #Inhibitors #Diagnosis #Differential #Indications
TNF-alpha Inhibitors ... #TNFalpha #Inhibitors ... #Diagnosis #Differential