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diagnosis hematology algorithm anemia causes extravascular hemolysis intravascular nutrition anemias calculation comparison defects dermatology folate folicacid index inherited nonpalpable palpable
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
- Differential ... Diagnosis Algorithm Signs ... Extrinsic RBC Defects ... Intrinsic RBC Defects ... : Membrane defects
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
- Differential ... Abnormal Hgb & Hgb Defects ... Hgb - Membrane Defects ... - RBC Enzyme Defects ... • PK deficiency
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
- Differential ... , Other enzyme defects ... Unstable hemoglobin defects ... Glutathione metabolism defects ... #Anemia #Differential
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Intrinsic RBC Defects ... G6PD deficiency) ... thalassemias), Membrane defects ... Extravascular #Causes #differential ... #diagnosis #hematology
Clinically Important Vitamins and Vitamin Deficiency States Fat-soluble Vitamins: • Vitamin A - Xerophthalmia, night blindness,
Vitamins and Vitamin Deficiency ... • Vitamin E - Haemolytic ... Anaemia, neural tube defects ... #differential # ... diagnosis #signs
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
deficiencies: Iron deficiency ... Microangiopathic hemolytic ... Intrinsic RBC defects ... cell anemia, G6PD deficiency ... #anemia #differential
Inherited Qualitative Platelet Defects Bernard-Soulier Syndrome • Defect of adhesion due to a lack of GP Ib/IX/V
Qualitative Platelet Defects ... a storage pool deficiency ... Inherited #Platelet #Defects ... #comparison #table ... #differential #
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Thrombocytopenia • Platelet defects ... PURPURA: Platelet Defects ... DIC/TTP/HUS - Hemolytic ... syndrome Coagulation Defects ... #rheumatology #
Etiologies of Folate Deficiency • Decreased dietary intake - uncommon in this era • Increased requirements
Etiologies of Folate Deficiency ... pregnant have hemolytic ... Alcohol - Alcohol affects ... #FolicAcid #differential ... #diagnosis #hematology
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