11 results
GLP-1 Receptor Agonists - Pharmacology Summary
Mechanisms of Action: Stimulate glucose-dependent insulin release from the pancreas (GLP-1
- Pharmacology ... Ozempic), or daily tablet ... pancreatitis Common Side Effects ... Toxicities: • Gl side effects ... DM2 #diabetes #endocrinology
GLP-1 Agonists

Adlyxin (Lixisenatide) Daily
Bydureon (Exenatide ER) Weekly 
Ozempic (Semaglutide) Weekly 
Trulicity (Dulaglutide) Weekly 
Victoza (Liraglutide) Daily
to the incretin effect ... Common side effects ... There is an ORAL ... #Pharmacology #Dosing ... Diabetes #DM2 #Endocrinology
DPP-4 Inhibitors - Pharmacology Summary
Mechanisms of Action: Inhibits DPP-4 (dipeptidyl peptidase 4), which normally inactivates GLP-1
4 Inhibitors - Pharmacology ... GLP-I receptor agonist ... failure Common Side Effects ... definitively cause/effect ... DM2 #diabetes #endocrinology
Rybelsus (oral semaglutide) - First Oral GLP-1 Agonist
Dosing:
3 mg daily x 30 days, then 7 mg
-1 Agonist Dosing ... drug to remain stable ... upset as a side effect ... semaglutide #Diabetes #Pharmacology ... #Endocrinology
DPP4 Inhibitors - Normal and Renal Dosing

Increase Incretins (GLP-I & GIP) -> Stimulates Insulin, Inhibits Glucagon
titrate up to effects ... only few side effects ... #Pharmacology # ... Management #Diabetes ... #DM2 #Endocrinology
Acromegaly - Diagnosis and Management Summary - GrepMed Handbook 

Clinical Presentation: 
 • Classic Acromegaly: frontal
Macroadenoma direct effects ... multisystemic anabolic effects ... IGF-1 equivocal: Oral ... Pegvisomant) ± D2 agonist ... #Endocrinology
Summary of actions of some Cholinergic Agonists

Bethanechol 
• Used in treatment of urinary retention 
• Binds
some Cholinergic Agonists ... CNS and cardiac effects ... • Reverses CNS effects ... #Pharmacology # ... Table #Summary
Perioperative Management of DOACs
Problem:
 ✖ Each year approximately 250,000 patients on chronic anticoagulation in North America
Perioperative Management ... direct acting oral ... anticoagulant effect ... per treatment table ... #Treatment #pharmacology
IDSA - Clinical Strategy to Build an Individualized Treatment Regimen for Multi-Drug Resistant Tuberculosis (MDR-TB)
 •
significant adverse effects ... five effective oral ... Tuberculosis #MDRTB #management ... antimicrobials #regimens #pharmacology ... #dosing #idsa #
It is important to recognize Acute Decompensated Heart Failure (ADHF) as more than just simply a
Signs of congestion ... transitioning to oral ... differential #algorithm #management ... cardiology #treatment #table ... icu #clinical #pharmacology