13 results
Diabetes Combination Tablets - Estimated A1c Lowering 
Metformin + DPP4 
• Janumet (metformin + sitagliptin) 
•
Metformin + DPP4 ... Metformin + SGLT2 ... dapagliflozin) Dpp4 ... Tablets #Oral #DM2 #Pharmacology ... #Pills #Endocrinology
Mechanism of Action for Common Diabetes Medications

 • SGLT2i (Dapagliflozin)
 • TZD (Pioglitazone)
 • Biguanides (Metformin)
Medications • SGLT2i ... Receptor Agonists • DPP4i ... #Medications #pharmacology ... pathophysiology #endocrinology
DPP-4 Inhibitors - Pharmacology Summary
Mechanisms of Action: Inhibits DPP-4 (dipeptidyl peptidase 4), which normally inactivates GLP-1
DPP-4 Inhibitors ... - Pharmacology ... failure Common Side Effects ... #Inhibitors #Pharmacology ... DM2 #diabetes #endocrinology
Diabetes Medications Summary Table
Insulin
Lifestyle modifications
Metformin
Sulfonylureas
GLP-1 receptor agonists - ↓ major adverse CV events
TZDs
DPP-4 inhibitors
SGLT2 inhibitors -
events TZDs DPP ... -4 inhibitors SGLT2 ... table #comparison #management ... #endocrinology
DPP4 Inhibitors - Normal and Renal Dosing

Increase Incretins (GLP-I & GIP) -> Stimulates Insulin, Inhibits Glucagon
titrate up to effects ... only few side effects ... Renal #Dosing #Pharmacology ... #Management #Diabetes ... #DM2 #Endocrinology
Effects on body weight of various classes of type-2 diabetes medications.
 - Metformin - Weight Loss
Effects on body ... Weight Loss + - SGLT ... Weight Loss +++ - DPP ... weightgain #comparison #pharmacology
SGLT2 Inhibitors - Pharmacology Summary
Mechanisms of Action: Inhibits SGLT2 (sodium/glucose cotransporter 2) in the proximal tubule,
SGLT2 Inhibitors ... - Pharmacology ... ) Common Side Effects ... #Inhibitors #Pharmacology ... DM2 #diabetes #endocrinology
SGLT2 Inhibitors 
SGLT2 inhibitors are the newest class of anti-diabetic medications, with the first one (Canagliflozin)
SGLT2 Inhibitors ... SGLT2 inhibitors ... /ambcarerx #SGLT2 ... #Inhibitors #Pharmacology ... DM2 #Diabetes #Endocrinology
Oral Hypoglycemics in Diabetes Management
1  INSULIN SENSITIZER
 • TZD 
     -
Hypoglycemics in Diabetes Management ... Prandase) • SGLT ... (Adlyxin) • DPP ... by inhibiting DPP ... #pharmacology #
Euglycemic Diabetic Ketoacidosis (EuDKA)
SGLT2 Inhibitors
Increasing Indications
Significant Adverse Drug Effects
Definition of EuDKA
 • Metabolic acidosis with pH
Ketoacidosis (EuDKA) SGLT2 ... Significant Adverse Drug Effects ... EuDKA #diagnosis #management ... #endocrinology