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diagnosis differential erythematosus lupus signs vasculitis ana antibodies antinuclear autoantibodies autoimmune chronic classification cll comparison druginduced hematology hypnotic leukemia lymphocytic
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Lupus (SLE) General ... Restrictive lung defect ... Thrombocytopenia #Lupus #SLE ... #signs #symptoms ... #diagnosis #rheumatology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
technique used to detect ... context of other symptoms ... disease (MCTD), Drug-induced ... Biliary Cirrhosis, Drug-Induced ... ANA #patterns #rheumatology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... Lupus Mimickers: Drug-induced ... autoantibodies #signs ... #symptoms #mimickers ... #differential #rheumatology
Drug Induced Systemic Lupus Erythematosus > 100 drugs have been associated with drug-induced SLE High risk (>5%): •
Drug Induced Systemic ... SLE High risk ... Erythematosus #medications ... #drugs #pharmacology ... differential #diagnosis #rheumatology
Sedative-Hypnotic Drugs Benzodiazepines: - Bind to specific GABAA receptor subunits at central nervous system (CNS) neuronal synapses
Sedative-Hypnotic Drugs ... central nervous system ... or withdrawal symptoms ... sedative-hypnotic drugs ... #medications #pharmacology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... extremities Drug ... Induced Lupus: • Symptoms ... • Antihistone: Drug ... activation and/or medications
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
diseases, such as SLE ... atherosclerotic disease, drug ... Symptoms (SX) in ... purpura: Strong sign ... Differential #Diagnosis #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
vasculitis) - Affects ... Symptoms (Sx) in ... purpura: strong sign ... vasculitis, and SLE ... differential #diagnosis #rheumatology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
rendering the immune system ... • M > F • Affects ... with no early symptoms ... Physical Exam/Signs ... ’s CLL Scoring system
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
infectious, thyroid, drug-induced ... RP-ILD), dermato-rheumatologic ... papules and Gottron sign ... ) • Shawl sign ... • Conduction system
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