449 results
diagnosis differential causes algorithm hematology management clinical signs symptoms pathophysiology workup neurology cardiology hemolytic deficiency nephrology pediatrics mnemonic pharmacology treatment
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
Hemolytic Anemias ... Algorithm Signs of anemia ... Autoimmune Hemolytic Anemias ... defects, Enzyme deficiencies ... #Hemolytic #Anemias
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
particular degree of anemia ... Index < 2: • Anemia ... inflammation • Nutrient deficiencies ... Folate • Hormone deficiencies ... failure: Aplastic anemia
Micronutrient Deficiencies After Gastric Bypass Fat-Soluble Vitamins: • Vitamin A - Night/complete blindness, xeropthalmia (pathologic dryness of
Micronutrient Deficiencies ... Folate - Macrocytic anemia ... B12 - Macrocytic anemia ... Minerals: • Iron - Anemia ... uw_IMresidency #nutrient #Deficiencies
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm Sequestration: • Splenomegaly Marrow Infiltration: • Hematologic and non-hematologic
Toxins • Aplastic Anemia ... folate/combined deficiencies
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
deficiency • Fanconi’s anemia ... Nutritional Deficiencies
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
for Hemolytic Anemia ... Causes: • Enzyme deficiencies ... #Hemolytic #Anemia
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Microangiopathic hemolytic anemia ... Defects: Enzyme deficiencies ... diagnosis #hematology #anemia
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
cause nutrient deficienies ... changes), high MCV anemia
Lactic Acidosis - Differential Diagnosis Framework Type A: Impaired O2 Delivery (DO2) • Decreased O2 Delivery: Hypotension
Shock, Severe Anemia ... lactic acidosis, Deficiencies
Scurvy (Vitamin C Deficiency) - Diagnosis and Management Vitamin C is required for hydroxylation of proline residues
breath, wasting, anemia ... Loss of teeth Anemia ... iron and folate deficiencies
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