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diagnosis differential algorithm macrocytosis elevatedmcv folate folicacid vitamin aafp b12 bariatric bypass cobalamin deficiencies dermatology gastric homocysteine management mcv mds
Approach to Hypoproliferative Macrocytic Anemia • 812, Folate Deficiency • MDS+ • Hypothyroid • Liver Disease
Hypoproliferative Macrocytic ... Anemia • 812 ... , Folate Deficiency ... diagnosis #algorithm #hematology ... #workup
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
" • Iron deficiency ... MCV - >96fL - "Macrocytic ... , Folate deficiency ... differential #diagnosis #causes ... #hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... • Drugs Oval Macrocytes ... • Dietary Deficiency ... B12 and Folate Deficiency ... #Hematology
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm Sequestration: • Splenomegaly Marrow Infiltration: • Hematologic and non-hematologic
Causes of Neutropenia ... Toxins • Aplastic Anemia ... Myelodysplasia Nutritional ... deficiency: • ... Diagnosis #Algorithm #Causes
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... Polychromatic Macrocytes ... Polychromatic Macrocytes ... • Early Iron Deficiency ... #Hematology
Algorithm for the evaluation of macrocytic anemia. (RBC = red blood cell; MMA = methylmalonic acid.) Physicians
evaluation of macrocytic ... the most likely cause ... recovery also causes ... of the initial work-up ... if vitamin B12 deficiency
Micronutrient Deficiencies After Gastric Bypass Fat-Soluble Vitamins: • Vitamin A - Night/complete blindness, xeropthalmia (pathologic dryness of
• Thiamine - Nausea ... cardiomyopathy) • Folate - Macrocytic ... B12 - Macrocytic ... Bypass #vitamin #nutrition ... #table #differential
Causes of Anemia with Low Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased Heme Synthesis or
Causes of Anemia ... RBC>13 • Iron Deficiency ... Malabsorption, Dietary Deficiency ... #Microcytic #Anemia ... #Hematology
Etiologies of Folate Deficiency • Decreased dietary intake - uncommon in this era • Increased requirements
Etiologies of Folate Deficiency ... have hemolytic anemia ... folate that can cause ... differential #diagnosis #hematology ... #nutrition
Etiologies of Peripheral Neuropathy • Metabolic / Nutritional: DiabetesB12 deficiency, Uremia/ESRD, Hypothyroidism • Medication-induced: ART, Antibiotics,
• Metabolic / Nutritional ... : DiabetesB12 deficiency ... , Uremia/ESRD, Hypothyroidism ... differential #diagnosis #causes ... #neurology
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