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diagnosis oncology agglutinin atlas bloodcell chronic enlarged extravascular gap globulin hemolysis intravascular lymphocytic lymphomas lymphoproliferative management mds mentzerindex microscopy morphology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Red Blood Cell ( ... (sometimes) Macrocytic ... Unstable hemoglobin disorders ... hemolytic anemia ... #diagnosis #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
) (e.g. lupus, CLL ... , lymphoma, idiopathic ... lymphoproliferative disorders ... #differential # ... diagnosis #hematology
Causes of Splenomegaly - Differential Diagnosis Algorithm Infectious • Bacterial • Viral (EBV) • Parasitic • Fungal Congestive
Malignant • Lymphoma ... • Leukemia ... Serum Sickness Hemolytic ... Cell Disease (children ... #Causes #Hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
with no early symptoms ... • Neutropenia, anemia ... , Hodgkin’s lymphoma ... #diagnosis #workup ... #oncology #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
- Lymphoid Malignancy ... anemia • Cold ... younger pts) Differential ... #hemolytic #anemia ... #hematology #diagnosis
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Autoimmune disorders ... ingestion • B symptoms ... of cases) Classification ... Lymphoma Workup ... #hematology #oncology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Agglutination - Cold ... Consider RBC membrane disorder ... #Anemia #Differential ... #workup #hematology
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Disorders - Differential ... Hodgkin Lymphoma ... pattern of spread, B symptoms ... #Classification ... pathophysiology #Hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential ... plateletcount), peripheral blood ... pylori test (GI symptoms ... changes), high MCV anemia ... #Workup #hematology
Hematology Algorithms Anemia is described as a reduction in the proportion of the red blood cells.
Hematology Algorithms ... proportion of the red blood ... experience some symptoms ... three peripheral blood ... These causes could
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