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diagnosis differential oncology anemia management causes chronic cll leukemia lymphocytic workup atlas bloodcell cold cvid enlarged extravascular hemeonc hemolysis hodgkins
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
or lymphoid malignancy ... - Monoclonal - Lymphoid ... - most common presentation ... #disease #hemolytic ... #anemia #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
e.g. lupus, CLL, lymphoma ... . primary cold agglutin ... disorders, Mycoplasma ... e.g. sickle cell disease ... differential #diagnosis #hematology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
anemia (sometimes) Macrocytic ... Unstable hemoglobin disorders ... IgM associated lymphoma ... , Malignant lymphoma ... differential #diagnosis #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Differential Diagnosis Algorithm ... Agglutination - Cold agglutinins ... Consider RBC membrane disorder ... Differential #Diagnosis #Algorithm ... #workup #hematology
Causes of Splenomegaly - Differential Diagnosis Algorithm Infectious • Bacterial • Viral (EBV) • Parasitic • Fungal Congestive
Differential Diagnosis Algorithm ... Malignant • Lymphoma ... Myeloproliferative disorders ... Serum Sickness Hemolytic ... #Causes #Hematology
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Disorders - Differential ... Diagnosis Algorithm ... pattern of spread, B symptoms ... #Classification ... pathophysiology #Hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Autoimmune disorders ... nodosum • Immune hemolytic ... ingestion • B symptoms ... number of sites of disease ... #hematology #oncology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Immunodeficiency disorder ... hepatitis • Lymphoma ... • Nodules • Lymphoid ... and autoimmune hemolytic ... hypogammaglobulinemia #immunology #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Overview: • Most common ... leukemia in adults • Disorder ... to large cell lymphoma ... chemotherapy for low-risk disease ... Leukemia #oncology #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Epidemiology: • Most common ... with no early symptoms ... cells can indicate disease ... lymphoproliferative disorders ... workup #oncology #hematology
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