16 results
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Diagnosis Framework ... /Quantity: • Primary ... : ITP • Secondary ... - Hemolytic anemia ... #hematology #rheumatology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Decreased WBCs
 - Decreased/NormaI
Causes of Anemia ... - Differential Diagnosis ... Reticulocytosis • Primary ... Hypersplenism • Secondary ... #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... thrombocytopenic purpura ... usually IgM) (e.g. primary ... Hemoglobinopathies (e.g. sickle cell ... #hematology #anemia
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
15% of AIHA Primary ... Secondary Cold ... symptoms - most common ... malignancies - B-cell ... #hematology #diagnosis
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
activity • ↓ LAP Score ... - infiltrates (anemia ... + distinctive primary ... #Leukemia #Hematology ... #Oncology #Diagnosis
Causes of Neutropenia - Differential Diagnosis
Neonate:
 - Infection - by far the most common cause
 -
- Differential Diagnosis ... drug reactions - Secondary ... Megaloblastic anemia-rare ... including white blood cell ... #causes #hematology
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Most common cytopenia ... DDX: Rule Out Secondary ... CausesAnemia ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
Idiopathic CD4 Lymphopenia (ICL) / Lymphocytopenia 

DIAGNOSTIC CRITERIA FOR ICL
 • Persistent CD4 T-cell lymphopenia
 •
NO underlying primary ... or secondary immune ... MTB/MAC • Common ... #hematology #Differential ... #Causes #lymphocytopenia
Polycythemia - Differential Diagnosis Algorithm
Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
an underlying cause ... Too many cells in ... Better call hematology ... workup, think about common ... Algorithm #workup #hematology
Common Variable Immunodeficiency (CVID)

What?
CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
infection risk secondary ... to impaired B-cell ... DDX - Other causes ... hypogammaglobulinemia #immunology #hematology ... #diagnosis #management