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diagnosis differential management algorithm syndrome chronic classification diffuse hodgkins lad lymphocytic mds myelodysplastic workup acute aplastic cell comparison disorders focal
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
activity • ↓ LAP Score ... Blast crises • ... - infiltrates (anemia ... lymphoma #Leukemia ... #Hematology #Oncology
Causes of Diffuse and Localized Lymphadenopathy - Differential Diagnosis Algorithm • Reactive (Inflammatory / Infectious) •
Causes of Diffuse ... and Localized Lymphadenopathy ... • Neoplastic (Leukemia ... , Lymphoma, Metastatic ... #Hematology #Oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
• Neutropenia, anemia ... microglobulin Treatment ... leukemia #CLL ... diagnosis #workup #oncology ... #hematology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Causes of Diffuse ... Lymphadenopathy ... Non-Hodgkin's Lymphoma ... • Hodgkin's Lymphoma ... #Hematology #Oncology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
5) Symptoms of anemia ... lymphoma (Richter ... marrow failure with anemia ... uw_IMresidency #CLL ... #oncology #hematology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
involved) • No leukemic ... disease: B symptoms, lymphadenopathy ... • Other hematologic ... NonHodgkins #comparison #oncology ... #differential #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
old, ~10,000 new cases ... cytopenias (usually anemia ... transformation to acute leukemia ... Allogeneic stem cell ... #hematology #oncology
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
(NHL) ~60% - lymphadenopathy ... Responsive to Treatment ... Treated Like Acute Leukemias ... growth, response to treatment ... pathophysiology #Hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Presentation: • Lymphadenopathy ... Weight loss • Anemia ... Treatment • Early ... classification #hematology ... #oncology #management
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Out Secondary Causes ... Chronic Myelogenous Leukemia ... Leukemia • Idiopathic ... Syndromes #diagnosis #hematology ... #oncology
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