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hematology amyloidosis clinical differential emergencies gammopathy hemeonc leukemia mds mgus monoclonal myelodysplasia myelodysplastic oncologic significance syndromes
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis Neurologic-Centered: (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
- Differential Diagnosis ... Features: POEMS, AL amyloid ... capillary leak syndrome ... • Schnitzler syndrome ... #hematology #oncology
Amyloidosis - Summary Group of disorders associated with extracellular deposition of fibrils formed from low-molecular-weight proteins in
dyscrasias • Secondary ... Manifestations: Renal ... : • Nephrotic syndrome ... Carpal tunnel syndrome ... Testing: • EKG • Echocardiogram
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
develop leukostasis syndrome ... • Tumor lysis syndrome ... bone marrow and secondary ... #Leukemia #Hematology ... #Oncology #Diagnosis
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... DDX: Rule Out Secondary ... Workup: • Complete ... #diagnosis #hematology ... #oncology
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
full infectious work-up ... days → add fungal work-up ... Leukostasis: - Usually myeloid ... , hypotension, renal ... #HemeOnc #Diagnosis
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