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diagnosis sle classification differential erythematosus hcq hydroxychloroquine management systemic adverseeffects ana anca antibodies antibody antineutrophil antinuclear benefits diseases emergency hematology
Classification of Vasculitis Vasculitis of large vessels - Arteritis temporalis (giant-cell arteritis) - Takayasu
angiitis of the central ... Churg-Strauss syndrome ... - systemic lupus ... - Sjögren syndrome ... Vessels #Diagnosis #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
inflammation Others: • Lupus ... : • Behçet Syndrome ... • Cogan Syndrome ... such as systemic lupus ... differential #diagnosis #rheumatology
Pharmacologic Treatment of Hypertensive Emergencies in Pregnancy Drug - Dose range - Onset/oeak/duration - Side effects -
Pharmacologic Treatment ... , hypotension, lupus-like ... syndrome - Nifedipine ... Obstetrics #OBGyn #HTN #Pharmacology ... #Medications
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Features of Systemic Lupus ... Butterfly rash, Vasculitis ... Demyelinating syndromes ... Abdominal pain (20%) Renal ... symptoms #diagnosis #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
ANCA-associated vasculitis ... Non-autoimmune rheumatologic ... • Mesenteric vasculitis ... activation and/or medications ... Erythematosus #Diagnosis #Rheumatology
Hydroxychloroquine Serum Measurement in SLE • Terminal elimination half-life = 40 days ([HCQI reflects long-term intake)
200ng/mL Best indications ... Special cases (e.g. renal ... Measurement #SLE #rheumatology ... #pharmacology # ... levels #lupus #management
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
) • Systemic lupus ... cases • Sjögren syndrome ... ANCA-Associated Vasculitis ... vasculitis - MPO ... antibodies #diagnosis #rheumatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Autoimmunity: • -MM/WM: Vasculitis ... to cold IgG • Lupus ... vascular beds-renal ... Paraproteinemias #Hematology ... Differential #Diagnosis #Oncology
Hydroxychloroquine - Risks and Benefits in Lupus Benefits: ↓ Disease activity, ↓ Flare, ↓ Damage, ↓ Corticosteroid dose,
and Benefits in Lupus ... recommended with other medications ... Risks #Benefits #Lupus ... #pharmacology # ... #sideeffects #rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... ) • Cutaneous vasculitis ... : 2% Systemic Vasculitis ... lubricants • Pharmacologic ... #Rheumatology #
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