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differential hematology management vasculitis erythematosus systemic classification activation ana antibodies antibody antineutrophil antinuclear cryoglobulinemia cryoglobulins cutaneous diseases gap globulin joint
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
) • Systemic lupus ... in drug-induced SLE ... cases • Sjögren syndrome ... Antineutrophil #antibodies #diagnosis ... #rheumatology #
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Antinuclear (ANA ... severe disease & renal ... Associated with skin ... #Summary #diagnosis ... #rheumatology #
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
Antiphospholipid-antibody syndrome ... lesions • Discoid lupus ... Sarcoidosis #dermatology ... #differential #diagnosis ... #rheumatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Alpha & Mu) Skin ... to cold IgG • Lupus ... vascular beds-renal ... Paraproteinemias #Hematology ... #Differential #Diagnosis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Differential Diagnosis ... inflammation Others: • Lupus ... such as systemic lupus ... vasculitis, and SLE ... #rheumatology #
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... 3rd Decade Skin ... Differential Diagnosis ... Non-autoimmune rheumatologic ... #Rheumatology
Vasculitis Involving the Skin - Differential Diagnosis Framework Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis Secondary: CTD: SLE, RA
- Differential Diagnosis ... Secondary: CTD: SLE ... Vasculitis • ANCA ... Disease • Cogan syndrome ... #dermatology #rheumatology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
(SLE) General: ... Sjögrens (15%) Skin ... Demyelinating syndromes ... signs #symptoms #diagnosis ... #rheumatology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Differential Diagnosis ... purple, hemorrhagic skin ... Cryoglobulinemia (MIXED) • ANCA ... Associated - SLE ... #hematology #rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
- Purpura - Skin ... Labs/Diagnosis: ... DDX: • ANCA (Antineutrophil ... (e.g. systemic lupus ... classification #rheumatology
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