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diagnosis management cardiology hematology pharmacology acute aki als amyotrophic anthracycline apml cancer checkpoint chemotherapy classification differentiation druginduced hemophagocytic her2 hlh
Mechanisms of Drug-Induced Hyperkalemia • Direct renin inhibitor (Aliskiren) • Renin release inhibition (NSAIDs, Beta-Blockers)
• Direct renin inhibitor ... • Angiotensin II ... • Calcineurin Inhibitors ... #hyperkalemia #differential ... #diagnosis #pathophysiology
Management of Immune Checkpoint Inhibitor (ICI) Induced Cardiotoxicity Problem - Immune checkpoint inhibitors (ICIs) are associated with
(ICI) Induced Cardiotoxicity ... abatacept for the treatment ... #ICI #Cardiotoxicity ... #cardiology #oncology ... #management #treatment
Acute Kidney Injury (AKI) in Patients with Cancer Cancer Related • Hypercalcemia • Intravenous contrast •
malignancies Treatment ... sunitinib , PD-Ii ... #AKI #Cancer #Oncology ... #Differential #
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Triggers: ATRA treatment ... Pathophysiology ... initiation • Differential ... organ dysfuxtion, ICU ... management #hematology #oncology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... Unknown cause Treatment ... of emergency, ICU ... Anti-IFN-y and JAK inhibitors ... diagnosis #management #treatment
Amyotrophic Lateral Sclerosis (ALS) Summary ALS: combination of the clinical examination finding of amyotrophy with the pathologic
lateral sclerosis Pathophysiology ... conditions listed in differential ... diagnosis column Treatment ... Riluzole - An inhibitor
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
factor (GCSF) treatments ... blood count with differential ... marrow studies Treatment ... methyltransferase inhibitors ... diagnosis #hematology #oncology
Management of Anthracyclines and HER2 Antagonist Cardiotoxicity Anthracyclines cause cardiomyopathy: ✖ Reduction in left ventricular ejection fraction
HER2 Antagonist Cardiotoxicity ... ) and initiate treatment ... system (RAAS) inhibitor ... Anthracycline #HER2 #Cardiotoxicity ... #cardiology #oncology
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