28 results
Gout Management in CKD
 • Colchicine
 • NSAID
 • Glucocorticoid
 • ACTH
 • Interleukin-1 Inhibitors

#Gout #Management
Interleukin-1 Inhibitors ... Management #CKD #rheumatology ... #treatment #comparison
Mixing Study
 • Clotting tests can be abnormal due to either a clotting factor deficiency, or
deficiency, or an inhibitor ... deficiencies and inhibitors ... Patient has a factor inhibitor ... #pathophysiology ... #hematology #laboratory
Medications for Prevention of Chronic Gout
Colchicine (Colcrys)
Pegloticase (Krystexxa)
Probenecid
Xanthine oxidase inhibitors:
 - Allopurinol (Zyloprim)
 - Febuxostat (Uloric)
#Chronic
Xanthine oxidase inhibitors ... #Medications #Treatment ... Management #AAFP #Rheumatology
Initial treatment of renal bone disease and cinacalcet for secondary hyperparathyroidism
Phosphate binders reduce hyperphosphataemia and hyperparathyroidism.
Initial treatment ... the first-line treatments ... inhibits PTH release ... #Pharmacology #Pathophysiology
Behcet's Syndrome - Treatment
Ulcers:
 • Treatment: Topical steroids
 • Prevention: Colchicine
 • Azathioprine for refractory disease
Arthritis:
Behcet's Syndrome - Treatment ... Ulcers: • Treatment ... Azathioprine and/or TNF-α inhibitors ... azathioprine • TNF-α inhibitors ... #pharmacology #rheumatology
Approach to Gout
Diagnosis: r/o septic arthritis! Needle-shaped, negative birefringent crystals
Treatment:
 • Weight loss, diet, d/c culprit
birefringent crystals Treatment ... Acute and chronic treatment ... Xanthine Oxidase Inhibitors ... diagnosis #management #treatment ... #ULT #rheumatology
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
pharmacological inhibitors ... diagnosis #models #hematology ... #pathophysiology ... Dabigatran #thrombin #inhibitor
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓)
of cytochrome p450 CYP3A4 and P-glycoprotein.

DOACs are substrates
interactions) Cancer-treatment ... inducers (↑) and inhibitors ... concentrations, and inhibitors ... by inducers or inhibitors ... Chemotherapy #Oncology #Hematology
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... Unknown cause Treatment ... Anti-IFN-y and JAK inhibitors ... diagnosis #management #treatment ... #summary #rheumatology
Chronic Lymphocytic Leukemia (CLL) - Summary
Overview: 
 • Most common leukemia in adults
 • Disorder of
transformation) Treatment ... AIHA, PRCA) • Treatment ... (Bruton kinase inhibitor ... Venetoclax (BCL2 inhibitor ... Leukemia #oncology #hematology