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diagnosis oncology clinical pathology anemia apl approach auer cancer differentiation disorders eosinophilia hypersegmented increased lymphomas lymphoproliferative management mds myelodysplasia myelodysplastic
Hypersegmented neutrophil in a case of acute myeloid leukemia. Dysplastic neutrophils are typically hypolobated but can be
in a case of acute ... myeloid leukemia ... #AML #Clinical ... #Hematology #Pathology ... #Smear
Acute promyelocytic leukemia (blood). Typical morphologic features are bilobed ("butterfly") nuclei with dispersed chromatin, subtle to
leukemia (blood ... features in most cases ... #APL #APML #Pathology ... #Hematology #Clinical ... #Smear
Causes of Neutrophilia - Increased Neutrophils - Differential Diagnosis Algorithm Infection • Bacterial • Abscess • Viral Medications
Causes of Neutrophilia ... - Differential ... Diagnosis Algorithm ... Polycythemia vera Acute ... #Causes #Hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
APML, CLL Acute ... ALL (Acute Lymphoblastic ... -> AML: Blast crises ... Leukemia): • Neutrophils ... #Hematology #Oncology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
- Differential ... Chronic Myelogenous Leukemia ... Infectious: • Acute ... disorders • Celiac ... #Causes #Hematology
Causes of Eosinophilia - Differential Diagnosis Bugs: - Fungus (aspergillosis) - Viral (HIV) - Ectoparasites (scabies, myiasis)
- Differential ... Rhinitis - Allergic Dermatitis ... Primary: - CML ... Mastocytosis - Acute ... #hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Diagnosis Algorithm ... Blood Loss • Acute ... Normochromic RBCs on Smear ... Non-lmmune #Anemia #Classification ... #Causes #Hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome in APML ... Incidence: common in APL ... febrile neutrophilic ... Differentiation #Syndrome #APML ... diagnosis #management #hematology
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Diagnosis Algorithm ... Treated Like Acute ... Leukemias, very ... Lymphoproliferative #Disorders #Classification ... pathophysiology #Hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
(hypogranular neutrophils ... transformation to AML ... blood count with differential ... progression to AML ... Syndromes #diagnosis #hematology
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