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aflp apml arterial bleeding bruising coagulation dic differentiation embolism fatty hemostasis intravascular nonpalpable obgyn obstetrics oncology palpable pregnancy purpura rheumatology
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... = nonspecific (nausea ... infiltration) Differential ... #Pregnancy #hepatology ... #management #pathophysiology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
deficiency • Liver ... - APLS • Acute ... Pigmented Purpuric Dermatosis ... #Diagnosis #hematology ... #nonpalpable #dermatology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Syndrome, Ischemic Liver ... thrombocytopenia - Disseminated ... coagulation and other causes ... Venous #Arterial #pathophysiology ... #hematology #differential
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
malignancy (Especially acute ... protein C and S Pathophysiology ... DIC • Severe Liver ... #Coagulation #diagnosis ... #management #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
ATRA treatment Pathophysiology ... • Rare: DAH, acute ... febrile neutrophilic dermatosis ... initiation • Differential ... #management #hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
of Hemostasis - Differential ... Diagnosis Framework ... failure, disseminated ... discern these causes ... #Diagnosis #Hematology
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