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coagulation abnormal aptt pt apml arterial bleeding bruising dic differentiation embolism hemostasis intravascular nonpalpable oncology palpable purpura syndrome thrombosis treatment
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... • Reduced liver ... hemorrhage • Disseminated ... #Causes #diagnosis ... hematology #coagulation
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Early liver disease ... Disseminated intravascular ... #Causes #diagnosis ... #differential # ... hematology #coagulation
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
deficiency • Liver ... - APLS • Acute ... #Diagnosis #hematology ... #rheumatology # ... #nonpalpable #dermatology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
malignancy (Especially acute ... Thrombocytopenia • Prolonged ... DIC • Severe Liver ... #Coagulation #diagnosis ... #management #hematology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Syndrome, Ischemic Liver ... thrombocytopenia - Disseminated ... coagulation and other causes ... Venous #Arterial #pathophysiology ... #hematology #differential
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
ATRA treatment Pathophysiology ... • Rare: DAH, acute ... febrile neutrophilic dermatosis ... initiation • Differential ... #management #hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
Diagnosis Framework ... the PT remains prolonged ... failure, disseminated ... discern these causes ... #Diagnosis #Hematology
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