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Thrombotic Microangiopathies In Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#TMAs #Thrombotic #Microangiopathies #Systemic #Lupus #Erythematosus #SLE #hematology
Lupus Erythematosus ... #SLE #hematology ... #rheumatology # ... differential #diagnosis ... #causes
Renal Involvement in Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#Renal #diseases #SLE #Systemic #Lupus #Erythematosus #venn #nephrology
Lupus Erythematosus ... Renal #diseases #SLE ... #Systemic #Lupus ... nephrology #nephritis #classification ... #types #rheumatology
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus
Clinical Domains:
 • Constitutional domain: Fever
 • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... pericarditis • Hematologic ... #Criteria #SLE ... #Systemic #Lupus ... Erythematosus #diagnosis #rheumatology
I’M DAMN SHARP - Lupus Diagnosis Mnemonic
I  	 Immunoglobulins (Anti-dsDNA, Anti-Sm, Anti-phospholipid)
M 	 Malar Rash
D
A Antinuclear Antibody ... Pleuritis) H Hematologic ... #IMDAMNSHARP #sle ... #systemic #lupus ... erythematosus #rheumatology
Lupus Classification
Spontaneous Lupus
 - Cutaneous Lupus Erythematosus (CLE)
 - Systemic Lupus Erythematosus 
Drug-Induced Lupus
 - Drug-Induced
Lupus Classification ... ) - Systemic Lupus ... #Classification ... #rheumatology # ... diagnosis #differential
ANA Patterns and Associated Rheumatic Diseases:
 • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
(SLE), Mixed connective ... (SLE), Sjogren's ... (SLE), Systemic ... ANA #patterns #rheumatology ... #diagnosis #differential
Vesiculobullous Skin Rash - Differential Diagnosis Algorithm
Vesicles Fragile/EasiIy Ruptured - Intraepidermal blisters, possibly crusts/erosions
 - Inflammatory
• Bullous systemic ... lupus erythematous ... Vesiculobullous #SkinRash ... #dermatology #Differential ... Diagnosis #Algorithm #causes
SLICC SLE Diagnostic Criteria - Systemic Lupus Erythematosus
Clinical and Immunologic Criteria

CLINICAL CRITERIA
 - ACUTE CUTANEOUS LUPUS
SLICC SLE Diagnostic ... Criteria - Systemic ... - Anti-dsDNA antibody ... #Diagnosis #Rheumatology ... #SLE #Lupus #Erythematosus
Autoantibodies in Rheumatology
 • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... • Lupus (SLE): ... (anti-nuclear antibody ... • Scleroderma (Systemic ... Autoantibodies #Rheumatology
Pancytopenia - Differential Diagnosis

Congenital Diseases:
• GATA2 deficiency
• Fanconi’s anemia
• Wiskott-Aldrich syndrome
• Ribosomopathy or telomeropathy

Cancer:
• Leukemia
• Lymphoma

Inflammatory
Pancytopenia - Differential ... Autoimmune Diseases: • Systemic ... lupus erythematosus ... hemoglobinuria • Antibody-mediated ... #Diagnosis #Hematology