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ana systemic autoantibodies patterns sle alopecia antibody antineutrophil aortitis arthritis causes cryoglobulinemia cryoglobulins dermatologic enlarged glomerulonephritis gpa granulomatosis hair hairloss
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
connective tissue disease ... 90% • Anti-GBM disease ... #antibodies #diagnosis ... #rheumatology # ... diseases
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
Associated Rheumatic Diseases ... connective tissue disease ... #Antibodies #ANA ... #patterns #rheumatology ... #diagnosis #differential
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... Disease! ... #Antibodies #ANA ... #patterns #rheumatology ... #diagnosis #differential
Classification of Vasculitis Vasculitis of large vessels - Arteritis temporalis (giant-cell arteritis) - Takayasu
Classification of ... small vessels - ANCA-associated ... - systemic lupus ... erythematosus ... #Diagnosis #Rheumatology
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
infection • Lyme disease ... migrans • Lyme disease ... Sarcoidosis • Crohn's disease ... Sarcoidosis #dermatology ... #diagnosis #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
(Granulomatous disease ... rheumatic diseases ... atherosclerotic disease ... differential #diagnosis ... #rheumatology #
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Decade Skin Disease ... Classification: ... Diagnosis: • ANCA-associated ... diseases (i.e. ... #Diagnosis #Rheumatology
Aortitis - Differential Diagnosis Framework Non-Infectious Aortitis: • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
polychondritis, Behcet's Disease ... ) • Rheumatic Diseases ... : IgG4-Related Disease ... erythematosus ( ... #Diagnosis #rheumatology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Post-strep GN, Lupus ... involvement: Anti-GBM Disease ... #differential # ... diagnosis #algorithm ... #rheumatology
Causes of Splenomegaly - Differential Diagnosis Algorithm Infectious • Bacterial • Viral (EBV) • Parasitic • Fungal Congestive
Diagnosis Algorithm ... • Gaucher's Disease ... Erythematosus ... #Diagnosis #Algorithm ... #Causes #Hematology
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