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syndrome management rheumatology signs agglutinin anemia behcet classification cold dermatologic dermpath gap globulin granulomatosis hemolytic hodgkins lesions myelodysplastic paraproteinemias pathology
Dermatological semiology of Cutaneous Vasculitis Clinicopathologic correlations • Purpura, papules, pustules, necrosis: involvement of small vessels
Identification of causes ... Connective tissue disease ... (5%): PAN > GPA ... #dermatology #semiology ... #clinical #manifestations
Cutaneous manifestations associated with myelodysplastic syndrome • Myeloid hemopathy with the most frequent skin lesions (20%)
Cutaneous manifestations ... appearing during the disease ... Neutrophilic dermatosis ... #diagnosis #dermatology ... #oncology #clinical
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
Dermatologic Manifestations ... GPA causes disease ... Diagnosis: Vasculitis ... #dermatology #rash ... #diagnosis #rheumatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Marginal Zone Lymphoma ... gangrenosum • Cutaneous ... Paraproteinemias #Hematology ... #Monoclonal #Differential ... #Diagnosis #Oncology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cryoglobulins (Vasculitic ... Viral Infection Clinical ... presentation) • Cutaneous ... Diagnosis Monoclonal ... hemolytic #anemia #hematology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Manifestations: ... ) • Cutaneous Lesions ... ) Differential Diagnosis ... Ischemia, Leukemia, Lymphoma ... : monoclonal TNF-aIpha
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... Causes of Monoclonal ... gastric tumors • Hematology ... #ProteinGap #differential ... #diagnosis #hematology
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
with systemic disease ... Most common extra cutaneous ... Causes: - Idiopathic ... (malignancy), lymphoma ... #dermatology #oncology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
- Clinical Presentation ... Workup: • Full ... Immunohistochemical studies (to differentiate ... number of sites of disease ... #hematology #oncology
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